SKP1

Gene Symbol	SKP1
Entrez Gene	6500
Alt Symbol	EMC19, OCP-II, OCP2, SKP1A, TCEB1L, p19A
Species	Human
Gene Type	protein-coding
Description	S-phase kinase-associated protein 1
Other Description	OCP-2|RNA polymerase II elongation factor-like protein OCP2|SIII|cyclin A/CDK2-associated p19|cyclin A/CDK2-associated protein p19|cyclin-A/CDK2-associated protein p19|organ of Corti protein 2|organ of Corti protein II|p19skp1|transcription elongation factor B polypeptide 1-like
Swissprots	D3DQ98 P63208 D3DQ97
Accessions	AAB50032 AAB50264 AAB50265 EAW62270 EAW62271 EAW62272 EAW62273 EAW62274 EAW62275 EAW62276 P63208 AI025746 AI028694 AK057110 BC009839 AAH09839 BC020798 AAH20798 BC025673 AAH25673 BC065730 AAH65730 BI552966 BI670085 BQ632052 DQ891512 ABM82438 DQ894703 ABM85629 EU831628 ACE87228 EU831713 ACE86547 U33760 AAC50241 U37558 AAA79202 Z47087 CAA87392 NM_006930 NP_008861 NM_170679 NP_733779
Function	Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(F
Top Pathways	Wnt signaling pathway, Cell cycle, Ubiquitin mediated proteolysis, TGF-beta signaling pathway, Circadian rhythm

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Skp1 full length protein - ab90687 from Abcam Category Protein Source E. coli Species Human

Human Skp1 full length protein - ab117211 from Abcam Category Protein Source E. coli Species Human

Human Skp1 peptide - ab24440 from Abcam Category Peptide

TCEB1 / Elongin C Antibody Blocking Peptide - LS-E3611 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TCEB1 / Elongin C Antibody Blocking Peptide - LS-E10940 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SKP1 Antibody Blocking Peptide - LS-E6597 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Skp1 Protein - NBP1-30173 from Novus Biologicals Category Protein Prices $279.00 Sizes 100 µg Species Human

Skp1 Partial Recombinant Protein - H00006500-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Skp1 Recombinant Protein - H00006500-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Skp1 Peptide - P0702 from Novus Biologicals Category Peptide Species Human

SKP1-Antibody-Center-Blocking-peptide - BP1937c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SKP1 Protein - GTX112041-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

SKP1 Alpha Protein (OPPA02111) - OPPA02111 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human SKP1 protein - orb246436 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human SKP1 Alpha protein - orb80869 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Species Human

SKP1 protein - 30R-1430 from Fitzgerald Category Protein Prices $220.00 Sizes 100 µg Source E.coli

SKP1 / OCP2 (1-160) - AR09313PU-L from Acris Antibodies Category Protein Prices $695.00 Sizes 500 µg Source E. coli Species Human

SKP1 / OCP2 (1-160) - AR09313PU-N from Acris Antibodies Category Protein Prices $305.00 Sizes 100 µg Source E. coli Species Human

SKP1 / OCP2 - H00006500-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SKP1 / OCP2 - H00006500-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SKP1 / OCP2 - H00006500-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SKP1 / OCP2 - H00006500-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SKP1, 1- 160aa, Human, E.coli - 01-1745 from ARP American Research Products Category Protein Prices $159.00, $339.00, $749.00 Sizes 20 µg, 100 µg, 500 µg Species Human

SKP1 fusion protein - Ag1457 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SKP1 Alpha Human - PKPS-363 from NeoScientific Category Protein Prices $65.00, $169.00, $2,925.00 Sizes 5 µg, 25 µg, 1 mg Source Escherichia Coli. Species Human

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