SKP1

Gene Symbol	SKP1
Entrez Gene	6500
Alt Symbol	EMC19, OCP-II, OCP2, SKP1A, TCEB1L, p19A
Species	Human
Gene Type	protein-coding
Description	S-phase kinase-associated protein 1
Other Description	OCP-2|RNA polymerase II elongation factor-like protein OCP2|SIII|cyclin A/CDK2-associated p19|cyclin A/CDK2-associated protein p19|cyclin-A/CDK2-associated protein p19|organ of Corti protein 2|organ of Corti protein II|p19skp1|transcription elongation factor B polypeptide 1-like
Swissprots	D3DQ98 P63208 D3DQ97
Accessions	AAB50032 AAB50264 AAB50265 EAW62270 EAW62271 EAW62272 EAW62273 EAW62274 EAW62275 EAW62276 P63208 AI025746 AI028694 AK057110 BC009839 AAH09839 BC020798 AAH20798 BC025673 AAH25673 BC065730 AAH65730 BI552966 BI670085 BQ632052 DQ891512 ABM82438 DQ894703 ABM85629 EU831628 ACE87228 EU831713 ACE86547 U33760 AAC50241 U37558 AAA79202 Z47087 CAA87392 NM_006930 NP_008861 NM_170679 NP_733779
Function	Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(F
Top Pathways	Wnt signaling pathway, Cell cycle, Ubiquitin mediated proteolysis, TGF-beta signaling pathway, Circadian rhythm

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Skp1 siRNA I - 12514 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

Skp1 p19 CRISPR/Cas9 KO Plasmid (h) - sc-418132 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Skp1 p19 HDR Plasmid (h) - sc-418132-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Skp1 p19 Double Nickase Plasmid (h) - sc-418132-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Skp1 p19 Double Nickase Plasmid (h2) - sc-418132-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Skp1 p19 CRISPR Activation Plasmid (h) - sc-418132-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Skp1 p19 CRISPR Activation Plasmid (h2) - sc-418132-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Skp1 p19 Lentiviral Activation Particles (h) - sc-418132-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Skp1 p19 Lentiviral Activation Particles (h2) - sc-418132-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Skp1 p19 siRNA (h) - sc-29482 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Skp1 p19 shRNA Plasmid (h) - sc-29482-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Skp1 p19 shRNA (h) Lentiviral Particles - sc-29482-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Skp1 RNAi - H00006500-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Skp1 RNAi - H00006500-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU134251 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK2082 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2086 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2085 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2084 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2087 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2083 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN19384 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19384 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09885 from Sigma-Aldrich Category miRNA

SKP1 siRNA (Human) - CRH4396 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Search more