HCAR3

Gene Symbol HCAR3
Entrez Gene 8843
Alt Symbol GPR109B, HCA3, HM74, PUMAG, Puma-g
Species Human
Gene Type protein-coding
Description hydroxycarboxylic acid receptor 3
Other Description G protein-coupled receptor 109B|G-protein coupled receptor 109B|G-protein coupled receptor HM74|G-protein coupled receptor HM74B|GTP-binding protein|hydroxy-carboxylic acid receptor 3|niacin receptor 2|nicotinic acid receptor 2|putative chemokine receptor
Swissprots A8K4G5 Q8NGE4 E9PI97 P49019 B2R830
Accessions ABX64359 BAC06083 EAW98335 EAW98336 P49019 AK290930 BAF83619 AK313212 BAG36027 BC038955 BC047891 AAH47891 BI908162 CB529340 CD366840 CU451507 D10923 BAA01721 DA948030 DA953971 R02740 NM_006018 NP_006009
Function Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. {ECO:0000269|PubMed:12522134, ECO:0000269|PubMed:19561068}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Expression largely restricted to adipose tissue and spleen. {ECO:0000269|PubMed:12522134}.
Top Pathways cAMP signaling pathway

HM74 (A-11) - sc-373932 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HM74 (A-11): sc-373932. Western blot analysis of HM74 expression in non-transfected: sc-117752 (A) and human HM74 transfected: sc-112381 (B) 293T whole cell lysates.

HM74 (D-8) - sc-377292 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HM74 (D-8): sc-377292. Western blot analysis of HM74 expression in non-transfected: sc-117752 (A) and human HM74 transfected: sc-112151 (B) 293T whole cell lysates.

HM74 (D-15) - sc-27874 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

HM74 (H-13) - sc-27876 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

HM74 (H-64) - sc-134582 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
HM74 (H-64): sc-134582. Western blot analysis of HM74 expression in Hep G2 (A), CCRF-CEM (B) and MCF7 (C) whole cell lysates.

HM74 (M-65) - sc-134583 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

HM74 (L-17) - sc-27877 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

HM74B (C-13) - sc-109538 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HM74B (C-13): sc-109538. Western blot analysis of HM74B expression in MOLT-4 (A), Jurkat (B), Hep G2 (C), CCRF-CEM (D), K-562 (E) and HL-60 (F) whole cell lysates.

Anti-GPCR HM74 antibody - ab136252 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-GPCR HM74 antibody (ab136252) at 1/500 dilution + HepG2 cell lysate at 30 µg

Anti-GPCR HM74 antibody - ab72112 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-GPCR HM74 antibody (ab72112) at 1 µg/ml + human liver lysate

Anti-GPCR HM74 antibody - N-terminal - ab150507 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human Adipocytes labeling GPCR HM74 with ab150507 at 4 µg/ml.

Anti-GPCR HM74 antibody - N-terminal - ab139073 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-GPCR HM74 antibody - N-terminal (ab139073) at 1/100 dilution + CEM cell line lysates at 35 µg

Anti-HCAR3 / GPR109B / HM74 Antibody - LS-C95997 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HCAR3 / GPR109B / HM74 Antibody (aa71-99, AP) - LS-C257955 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HCAR3 / GPR109B / HM74 Antibody (aa71-99, Biotin) - LS-C257957 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HCAR3 / GPR109B / HM74 Antibody (aa71-99, FITC) - LS-C257958 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HCAR3 / GPR109B / HM74 Antibody (aa71-99, APC) - LS-C257956 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HCAR3 / GPR109B / HM74 Antibody (aa71-99, PE) - LS-C257960 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HCAR3 / GPR109B / HM74 Antibody (aa71-99, Azide-free, HRP) - LS-C257959 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HCAR3 / GPR109B / HM74 Antibody - LS-C307746 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-HCAR3 / GPR109B / HM74 Antibody (aa71-99) - LS-C329595 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HCAR3 / GPR109B / HM74 Antibody (Thr327) - LS-C177092 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of HM74 (T327) pAb in extracts from RAW264.7 cells.

Anti-HCAR3 / GPR109B / HM74 Antibody (aa71-99) - LS-C159763 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
GPR109B Antibody western blot of CEM cell line lysates (35 ug/lane). The GPR109B antibody detected the GPR109B protein (arrow).

Anti-HCAR3 / GPR109B / HM74 Antibody (C-Terminus) IHC-plus™ - LS-A183 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GPR109B / HM74 antibody LS-A183 IHC of human adipocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-HCAR3 / GPR109B / HM74 Antibody (aa1-50) IHC-plus™ - LS-B1781 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GPR109B / HM74 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1781 concentration 10 ug/ml.
Search more