HCAR3

Gene Symbol	HCAR3
Entrez Gene	8843
Alt Symbol	GPR109B, HCA3, HM74, PUMAG, Puma-g
Species	Human
Gene Type	protein-coding
Description	hydroxycarboxylic acid receptor 3
Other Description	G protein-coupled receptor 109B|G-protein coupled receptor 109B|G-protein coupled receptor HM74|G-protein coupled receptor HM74B|GTP-binding protein|hydroxy-carboxylic acid receptor 3|niacin receptor 2|nicotinic acid receptor 2|putative chemokine receptor
Swissprots	A8K4G5 Q8NGE4 E9PI97 P49019 B2R830
Accessions	ABX64359 BAC06083 EAW98335 EAW98336 P49019 AK290930 BAF83619 AK313212 BAG36027 BC038955 BC047891 AAH47891 BI908162 CB529340 CD366840 CU451507 D10923 BAA01721 DA948030 DA953971 R02740 NM_006018 NP_006009
Function	Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. {ECO:0000269|PubMed:12522134, ECO:0000269|PubMed:19561068}.
Subcellular Location	Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Expression largely restricted to adipose tissue and spleen. {ECO:0000269|PubMed:12522134}.
Top Pathways	cAMP signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human GPCR HM74 full length protein - ab160220 from Abcam Category Protein Source Wheat germ Species Human

HCAR3 / GPR109B / HM74 Antibody Blocking Peptide - LS-E6499 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HCAR3 / GPR109B / HM74 Antibody Blocking Peptide - LS-E28407 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

HCAR3 / GPR109B / HM74 Antibody Blocking Peptide - LS-E28406 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

HCAR3 / GPR109B / HM74 Antibody Blocking Peptide - LS-E28409 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human GPR109B/HM74 Protein - H00008843-G01 from Novus Biologicals Category Protein Prices $569.00 Sizes 10 µg Source Wheat Germ Species Human

GPR109B-Antibody-N-term-Blocking-Peptide - BP19262a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GPCR HM74 blocking peptide - GTX30913 from GeneTex Category Peptide Prices $269.00 Sizes 50 μg Species Human

Nicotinic acid receptor 2 - H00008843-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

Nicotinic acid receptor 2 - H00008843-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Nicotinic acid receptor 2 - H00008843-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

NIACR2 fusion protein - ag13038 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant G Protein Coupled Receptor 109B (GPR109B) - RPG711Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

HM74 (T327) Peptide - BS2605P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant G Protein Coupled Receptor 109B (GPR109B) - RPG711Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human GPR109B/HM74 Protein - H00008843-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

HCAR3 Peptide, Human - M34GP06869H from Creative Peptides Category Peptide Source Synthetic. Species Human

Hydroxycarboxylic acid receptor 3 (HCAR3), Recombinant Protein - MBS7016524 from MyBioSource Category Protein Prices $1,195.00, $2,180.00, $3,385.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

Hydroxycarboxylic acid receptor 3 (HCAR3), Recombinant Protein - MBS1060455 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human HCAR3 Protein - HCAR3-5167H from Creative Biomart Category Protein Source Wheat Germ Species Human

Recombinant Human HCAR3 Protein, GST-tagged - HCAR3-5168H from Creative Biomart Category Protein Source Wheat Germ Species Human

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