HCAR3

Gene Symbol HCAR3
Entrez Gene 8843
Alt Symbol GPR109B, HCA3, HM74, PUMAG, Puma-g
Species Human
Gene Type protein-coding
Description hydroxycarboxylic acid receptor 3
Other Description G protein-coupled receptor 109B|G-protein coupled receptor 109B|G-protein coupled receptor HM74|G-protein coupled receptor HM74B|GTP-binding protein|hydroxy-carboxylic acid receptor 3|niacin receptor 2|nicotinic acid receptor 2|putative chemokine receptor
Swissprots A8K4G5 Q8NGE4 E9PI97 P49019 B2R830
Accessions ABX64359 BAC06083 EAW98335 EAW98336 P49019 AK290930 BAF83619 AK313212 BAG36027 BC038955 BC047891 AAH47891 BI908162 CB529340 CD366840 CU451507 D10923 BAA01721 DA948030 DA953971 R02740 NM_006018 NP_006009
Function Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. {ECO:0000269|PubMed:12522134, ECO:0000269|PubMed:19561068}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Expression largely restricted to adipose tissue and spleen. {ECO:0000269|PubMed:12522134}.
Top Pathways cAMP signaling pathway

HM74 CRISPR/Cas9 KO Plasmid (h) - sc-409435 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HM74 HDR Plasmid (h) - sc-409435-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HM74 Double Nickase Plasmid (h) - sc-409435-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HM74 Double Nickase Plasmid (h2) - sc-409435-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HM74 CRISPR Activation Plasmid (h) - sc-409435-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HM74 CRISPR Activation Plasmid (h2) - sc-409435-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HM74 Lentiviral Activation Particles (h) - sc-409435-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HM74 Lentiviral Activation Particles (h2) - sc-409435-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HM74 siRNA (h) - sc-105529 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HM74 shRNA Plasmid (h) - sc-105529-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HM74 shRNA (h) Lentiviral Particles - sc-105529-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GPR109B/HM74 RNAi - H00008843-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN9542 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9542 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06808 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06808

HCAR3 siRNA (Human) - CRH5839 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HCAR3 - MBS827613 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human HCAR3 (NM_006018.2) - SHH310725 from Creative biogene

Category siRNA
Species Reactivities Human

Human HCAR3 siRNA - orb266341 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HCAR3 shRNA Plasmid (Human) - CHH5839 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

HCAR3 miRNA 3'UTR clone - MiUTR1H-04176 from Creative biogene

Species Reactivities Human
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