| Gene Symbol |
HCAR3
|
| Entrez Gene |
8843
|
| Alt Symbol |
GPR109B, HCA3, HM74, PUMAG, Puma-g
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hydroxycarboxylic acid receptor 3
|
| Other Description |
G protein-coupled receptor 109B|G-protein coupled receptor 109B|G-protein coupled receptor HM74|G-protein coupled receptor HM74B|GTP-binding protein|hydroxy-carboxylic acid receptor 3|niacin receptor 2|nicotinic acid receptor 2|putative chemokine receptor
|
| Swissprots |
A8K4G5 Q8NGE4 E9PI97 P49019 B2R830
|
| Accessions |
ABX64359 BAC06083 EAW98335 EAW98336 P49019 AK290930 BAF83619 AK313212 BAG36027 BC038955 BC047891 AAH47891 BI908162 CB529340 CD366840 CU451507 D10923 BAA01721 DA948030 DA953971 R02740 NM_006018 NP_006009
|
| Function |
Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. {ECO:0000269|PubMed:12522134, ECO:0000269|PubMed:19561068}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expression largely restricted to adipose tissue and spleen. {ECO:0000269|PubMed:12522134}.
|
| Top Pathways |
cAMP signaling pathway
|