Gene Symbol | GZMM |
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Entrez Gene | 3004 |
Alt Symbol | LMET1, MET1 |
Species | Human |
Gene Type | protein-coding |
Description | granzyme M (lymphocyte met-ase 1) |
Other Description | HU-Met-1|Met-1 serine protease|granzyme M|lymphocyte met-ase 1|met-ase|natural killer cell granular protease |
Swissprots | P51124 |
Accessions | AAA57257 AAA57262 EAW61189 P51124 BC025701 AAH25701 CD366947 CR991101 HQ257986 ADR82740 L23134 AAA59582 NM_001258351 NP_001245280 NM_005317 NP_005308 |
Function | Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha- tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells. {ECO:0000269|PubMed:18523284, ECO:0000269|PubMed:20406824}. |
Subcellular Location | Secreted. Cytoplasmic granule. Note=Granules of large granular lymphocytes. |
Tissue Specificity | Highly and constitutively expressed in activated natural killer (NK) cells. {ECO:0000269|PubMed:18523284}. |
granzyme M (A-10) - sc-376799 from Santa Cruz Biotechnology
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granzyme M (C-10) - sc-393375 from Santa Cruz Biotechnology
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granzyme M (C-12) - sc-393155 from Santa Cruz Biotechnology
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granzyme M (G-15) - sc-51096 from Santa Cruz Biotechnology
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granzyme M (H-70) - sc-134862 from Santa Cruz Biotechnology
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granzyme M (L-14) - sc-51099 from Santa Cruz Biotechnology
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granzyme M (Q-14) - sc-51101 from Santa Cruz Biotechnology
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Anti-GZMM antibody - ab175566 from Abcam
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Anti-GZMM antibody - ab201102 from Abcam
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Anti-GZMM antibody - ab55226 from Abcam
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Anti-GZMM / Granzyme M Antibody (clone 4D11) - LS-C197391 from LifeSpan Bioscience
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Anti-GZMM / Granzyme M Antibody (aa26-257, Biotin) - LS-C298806 from LifeSpan Bioscience
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Anti-GZMM / Granzyme M Antibody (aa31-257, Biotin) - LS-C298807 from LifeSpan Bioscience
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Anti-GZMM / Granzyme M Antibody (aa19-251, Biotin) - LS-C298811 from LifeSpan Bioscience
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Anti-GZMM / Granzyme M Antibody (aa26-257, FITC) - LS-C305189 from LifeSpan Bioscience
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Anti-GZMM / Granzyme M Antibody (aa19-251, FITC) - LS-C305191 from LifeSpan Bioscience
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Anti-GZMM / Granzyme M Antibody (aa31-257, FITC) - LS-C305192 from LifeSpan Bioscience
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Anti-GZMM / Granzyme M Antibody (aa26-257) - LS-C294324 from LifeSpan Bioscience
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Anti-GZMM / Granzyme M Antibody (aa19-251) - LS-C294328 from LifeSpan Bioscience
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Anti-GZMM / Granzyme M Antibody (aa31-257) - LS-C294327 from LifeSpan Bioscience
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Anti-GZMM / Granzyme M Antibody (aa84-113) - LS-C166752 from LifeSpan Bioscience
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Granzyme M Antibody - NBP2-14079 from Novus Biologicals
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Granzyme M Antibody (4D11) - H00003004-M03 from Novus Biologicals
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Granzyme M Antibody - H00003004-A01 from Novus Biologicals
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ANTI-GZMM (CENTER) antibody produced in rabbit - SAB1303132 from Sigma-Aldrich
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