Gene Symbol |
GZMM
|
Entrez Gene |
3004
|
Alt Symbol |
LMET1, MET1
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
granzyme M (lymphocyte met-ase 1)
|
Other Description |
HU-Met-1|Met-1 serine protease|granzyme M|lymphocyte met-ase 1|met-ase|natural killer cell granular protease
|
Swissprots |
P51124
|
Accessions |
AAA57257 AAA57262 EAW61189 P51124 BC025701 AAH25701 CD366947 CR991101 HQ257986 ADR82740 L23134 AAA59582 NM_001258351 NP_001245280 NM_005317 NP_005308
|
Function |
Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha- tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells. {ECO:0000269|PubMed:18523284, ECO:0000269|PubMed:20406824}.
|
Subcellular Location |
Secreted. Cytoplasmic granule. Note=Granules of large granular lymphocytes.
|
Tissue Specificity |
Highly and constitutively expressed in activated natural killer (NK) cells. {ECO:0000269|PubMed:18523284}.
|