| Gene Symbol |
GZMM
|
| Entrez Gene |
3004
|
| Alt Symbol |
LMET1, MET1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
granzyme M (lymphocyte met-ase 1)
|
| Other Description |
HU-Met-1|Met-1 serine protease|granzyme M|lymphocyte met-ase 1|met-ase|natural killer cell granular protease
|
| Swissprots |
P51124
|
| Accessions |
AAA57257 AAA57262 EAW61189 P51124 BC025701 AAH25701 CD366947 CR991101 HQ257986 ADR82740 L23134 AAA59582 NM_001258351 NP_001245280 NM_005317 NP_005308
|
| Function |
Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha- tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells. {ECO:0000269|PubMed:18523284, ECO:0000269|PubMed:20406824}.
|
| Subcellular Location |
Secreted. Cytoplasmic granule. Note=Granules of large granular lymphocytes.
|
| Tissue Specificity |
Highly and constitutively expressed in activated natural killer (NK) cells. {ECO:0000269|PubMed:18523284}.
|