| Gene Symbol |
NCOA1
|
| Entrez Gene |
8648
|
| Alt Symbol |
F-SRC-1, KAT13A, RIP160, SRC1, bHLHe42, bHLHe74
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear receptor coactivator 1
|
| Other Description |
Hin-2 protein|PAX3/NCOA1 fusion protein|class E basic helix-loop-helix protein 74|renal carcinoma antigen NY-REN-52|steroid receptor coactivator-1
|
| Swissprots |
Q53SX3 Q13420 Q2T9G5 Q13071 O43792 O43793 Q6GVI5 O00150 Q7KYV3 Q15788
|
| Accessions |
AAX93184 ABS29266 EAX00746 EAX00747 EAX00748 Q15788 AJ000881 CAA04371 AJ000882 CAA04372 AK226063 AK290019 BAF82708 BC035976 BC111533 AAI11534 BC111534 AAI11535 BE675986 BF975824 CB047008 U19179 AAA64187 U40396 AAC50305 U59302 AAC50631 U90661 AAB50242 XM_005264625 XP_005264682 XM_005264626 XP_005264683 XM_005264627 XP_005264684 XM_005264628 XP_005264685 XM_011533141 XP_011531443 NM_003743 NP_003734 NM_147223 NP_671756 NM_147233 NP_671766
|
| Function |
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|Pu
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:15313887, ECO:0000269|PubMed:9427757}.
|