NCOA1

Gene Symbol	NCOA1
Entrez Gene	8648
Alt Symbol	F-SRC-1, KAT13A, RIP160, SRC1, bHLHe42, bHLHe74
Species	Human
Gene Type	protein-coding
Description	nuclear receptor coactivator 1
Other Description	Hin-2 protein|PAX3/NCOA1 fusion protein|class E basic helix-loop-helix protein 74|renal carcinoma antigen NY-REN-52|steroid receptor coactivator-1
Swissprots	Q53SX3 Q13420 Q2T9G5 Q13071 O43792 O43793 Q6GVI5 O00150 Q7KYV3 Q15788
Accessions	AAX93184 ABS29266 EAX00746 EAX00747 EAX00748 Q15788 AJ000881 CAA04371 AJ000882 CAA04372 AK226063 AK290019 BAF82708 BC035976 BC111533 AAI11534 BC111534 AAI11535 BE675986 BF975824 CB047008 U19179 AAA64187 U40396 AAC50305 U59302 AAC50631 U90661 AAB50242 XM_005264625 XP_005264682 XM_005264626 XP_005264683 XM_005264627 XP_005264684 XM_005264628 XP_005264685 XM_011533141 XP_011531443 NM_003743 NP_003734 NM_147223 NP_671756 NM_147233 NP_671766
Function	Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|Pu
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:15313887, ECO:0000269|PubMed:9427757}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human KAT13A / SRC1 protein fragment - ab81791 from Abcam Category Protein Source E. coli Species Human

Human KAT13A / SRC1 protein fragment - ab81812 from Abcam Category Protein Source E. coli Species Human

Human KAT13A / SRC1 protein fragment - ab81945 from Abcam Category Protein Source E. coli Species Human

Human KAT13A / SRC1 protein fragment - ab82062 from Abcam Category Protein Source E. coli Species Human

Human KAT13A / SRC1 protein fragment - ab82086 from Abcam Category Protein Source E. coli Species Human

Human KAT13A / SRC1 protein fragment - ab82205 from Abcam Category Protein Source E. coli Species Human

Human KAT13A / SRC1 protein fragment - ab81848 from Abcam Category Protein Source E. coli Species Human

KAT13A / SRC1 peptide - ab5848 from Abcam Category Peptide

NCOA1 / SRC-1 Antibody Blocking Peptide - LS-E1529 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NCOA1 / SRC-1 Antibody Blocking Peptide - LS-E12025 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NCOA1 / SRC-1 Antibody Blocking Peptide - LS-E9064 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SRC1 Protein - H00008648-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SRC1 Peptide - P2583 from Novus Biologicals Category Peptide Species Human

SRC1-Antibody-Center-Blocking-peptide - BP12262c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SRC1-Antibody-N-term-Blocking-Peptide - BP7570a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NCOA1 - H00008648-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NCOA1 - H00008648-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NCOA1 control peptide - SP5308CP from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

NCOA1 fusion protein - ag17978 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

NCOA1 fusion protein - ag16603 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human NCOA1, Receptor Interacting Domain - NCOA1-1160H from Creative Biomart Category Protein Source E. coli .

Recombinant Human NCOA1, Receptor Interacting Domain, Non-tagged - NCOA1-1161H from Creative Biomart Category Protein Source E. coli .

Recombinant Human NCOA1, RI Domain, TEV Cleavage Site - NCOA1-1162H from Creative Biomart Category Protein Source E. coli.

Recombinant Human NCOA1, His-tagged - NCOA1-29750TH from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human NCOA1, His-tagged - NCOA1-29751TH from Creative Biomart Category Protein Source E. coli Species Human

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