NCOA1

Gene Symbol	NCOA1
Entrez Gene	8648
Alt Symbol	F-SRC-1, KAT13A, RIP160, SRC1, bHLHe42, bHLHe74
Species	Human
Gene Type	protein-coding
Description	nuclear receptor coactivator 1
Other Description	Hin-2 protein|PAX3/NCOA1 fusion protein|class E basic helix-loop-helix protein 74|renal carcinoma antigen NY-REN-52|steroid receptor coactivator-1
Swissprots	Q53SX3 Q13420 Q2T9G5 Q13071 O43792 O43793 Q6GVI5 O00150 Q7KYV3 Q15788
Accessions	AAX93184 ABS29266 EAX00746 EAX00747 EAX00748 Q15788 AJ000881 CAA04371 AJ000882 CAA04372 AK226063 AK290019 BAF82708 BC035976 BC111533 AAI11534 BC111534 AAI11535 BE675986 BF975824 CB047008 U19179 AAA64187 U40396 AAC50305 U59302 AAC50631 U90661 AAB50242 XM_005264625 XP_005264682 XM_005264626 XP_005264683 XM_005264627 XP_005264684 XM_005264628 XP_005264685 XM_011533141 XP_011531443 NM_003743 NP_003734 NM_147223 NP_671756 NM_147233 NP_671766
Function	Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|Pu
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:15313887, ECO:0000269|PubMed:9427757}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SRC-1 CRISPR/Cas9 KO Plasmid (h) - sc-400879 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SRC-1 HDR Plasmid (h) - sc-400879-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SRC-1 Double Nickase Plasmid (h) - sc-400879-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SRC-1 Double Nickase Plasmid (h2) - sc-400879-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SRC-1 CRISPR Activation Plasmid (h) - sc-400879-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SRC-1 CRISPR Activation Plasmid (h2) - sc-400879-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SRC-1 Lentiviral Activation Particles (h) - sc-400879-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SRC-1 Lentiviral Activation Particles (h2) - sc-400879-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SRC-1 siRNA (h) - sc-36555 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SRC-1 shRNA Plasmid (h) - sc-36555-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SRC-1 shRNA (h) Lentiviral Particles - sc-36555-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SRC1 RNAi - H00008648-R02 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU081831 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15027 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15027 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11582 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr11582

NCOA1 siRNA (Human) - CRH5686 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SRC1 RNAi - H00008648-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

SRC1 RNAi - H00008648-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human NCOA1 (NM_003743.4) - SHH350072 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human NCOA1(NM_147223.2) - SHR001164 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human NCOA1(NM_147233.2) - SHR001200 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human NCOA1(NM_003743.4) - SHR001254 from Creative biogene Category siRNA Species Reactivities Human

Human NCOA1 siRNA - orb266188 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

NCOA1 shRNA Plasmid (Human) - CHH5686 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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