NCOA1

Gene Symbol NCOA1
Entrez Gene 8648
Alt Symbol F-SRC-1, KAT13A, RIP160, SRC1, bHLHe42, bHLHe74
Species Human
Gene Type protein-coding
Description nuclear receptor coactivator 1
Other Description Hin-2 protein|PAX3/NCOA1 fusion protein|class E basic helix-loop-helix protein 74|renal carcinoma antigen NY-REN-52|steroid receptor coactivator-1
Swissprots Q53SX3 Q13420 Q2T9G5 Q13071 O43792 O43793 Q6GVI5 O00150 Q7KYV3 Q15788
Accessions AAX93184 ABS29266 EAX00746 EAX00747 EAX00748 Q15788 AJ000881 CAA04371 AJ000882 CAA04372 AK226063 AK290019 BAF82708 BC035976 BC111533 AAI11534 BC111534 AAI11535 BE675986 BF975824 CB047008 U19179 AAA64187 U40396 AAC50305 U59302 AAC50631 U90661 AAB50242 XM_005264625 XP_005264682 XM_005264626 XP_005264683 XM_005264627 XP_005264684 XM_005264628 XP_005264685 XM_011533141 XP_011531443 NM_003743 NP_003734 NM_147223 NP_671756 NM_147233 NP_671766
Function Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|Pu
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:15313887, ECO:0000269|PubMed:9427757}.

SRC-1 (128E7) Rabbit mAb - 2191 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 128E7
Western blot analysis of cell extracts from various cell types using SRC-1 (128E7) Rabbit mAb.

SRC-1 (1135/H4) - sc-32789 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SRC-1 (1135/H4): sc-32789. Western blot analysis of SRC-1 expression in KNRK nuclear extract (A) and COS E2 whole cell lysate (B).

SRC-1 (C-20) - sc-6096 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SRC-1 (C-20): sc-6096. Western blot analysis of SRC-1 expression in K-562 nuclear extract.

SRC-1 (M-20) - sc-6098 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SRC-1 (M-20): sc-6098. Western blot analysis of SRC-1 expression in KNRK nuclear extract.

SRC-1 (M-341) - sc-8995 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ChIP analysis of <i>in vivo</i> binding of RORα and its recruitment of coactivators to RORα-responsive promoters in freshly dissected cerebella derived from wild type (+/+) and staggerer (Sg) mice. Control Input (A). Antibodies used included SRC-1 (M-341): sc-8995, SRC-1 (C-20): sc-6096 and SRC-1 (M-20): sc-6098 (B), Grip-1 (M-434): sc-8996 (C), NCoA-3 (F-2): sc-5305, NCoA-3 (M-397): sc-9119, NCoA-3 (N-17): sc-7217 and NCoA-3 (C-20): sc-7216 (D). Data kindly provided by M.G. Rosenfeld and reproduced wtih permission from Gold <i>et al</i>., Neuron 2003, 40: 1119-1131.

SRC-1 (6D775) - sc-73057 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

SRC-1 (8) - sc-136077 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/500 µl
Host Mouse
Clonality Monoclonal
SRC-1 (8): sc-136077. Western blot analysis of SRC-1 expression in Jurkat whole cell lysate.

Anti-KAT13A / SRC1 antibody - ab10308 from Abcam

Prices $387.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab10308 Immunoprecipitate KAT13A / SRC1 in human Huh-7 whole cell lysate. 1,000,000 cells were lysed and incubated with primary antibody at 4µg/mg lysate and Protein A matrix for 20 hours at 4°C. For western blotting an undiluted Abcam`s ab2859, Rabbit polyclonal to KAT13A / SRC1 was used.See Abreview

Anti-KAT13A / SRC1 antibody - ab5407 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-KAT13A / SRC1 antibody [1135/H4] - ChIP Grade - ab84 from Abcam

Prices $400.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1135/H4
Sonicated Chromatin prepared from untreated (UI) or 17beta-estradiol (E2) treated MCF7 cells was subjected to the ChIP procedure with ab84 to SRC1 and the immunoprecipitated chromatin was analysed in the proximal region of the estrogen-responsive pS2 promoter (as shown above) and quantified by real-time PCR (values are nomalized over inputs). The primers are designed to follow the nucleosome E (including the Estrogen Responsive Element ERE). 5 µl of ab84 and 2x106 cells were used in each ChIP experiment.

Anti-KAT13A / SRC1 antibody [3532C6a] - ab67101 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3532C6a
Anti-KAT13A / SRC1 antibody [3532C6a] (ab67101) + immunising recombinant fragment

Anti-KAT13A / SRC1 antibody - Aminoterminal end - ab71531 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KAT13A / SRC1 antibody - Aminoterminal end (ab71531) at 1/50 dilutionLane 1 : Non-transfected 293 cell line lysateLane 2 : KAT13A / SRC1 transfected 293 cell line lysateLysates/proteins at 2 µg per lane.

Anti-KAT13A / SRC1 antibody - N-terminal - ab135085 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-KAT13A / SRC1 antibody - N-terminal (ab135085) at 1/1000 dilution + 293T total cell extract

Anti-NCOA1 / SRC-1 Antibody (aa477-947, clone 1135) IHC-plus™ - LS-B1702 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1135
Anti-NCOA1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1702 concentration 5 ug/ml.

Anti-NCOA1 / SRC-1 Antibody (aa477-947) - LS-C10342 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-NCOA1 / SRC-1 Antibody (aa477-947) - LS-C10344 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-NCOA1 / SRC-1 Antibody - LS-C75958 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-NCOA1 / SRC-1 Antibody (aa8-24) - LS-C89255 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NCOA1 / SRC-1 Antibody (aa477-947) - LS-C83541 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-NCOA1 / SRC-1 Antibody - LS-C89257 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NCOA1 / SRC-1 Antibody (clone 3532C6a) - LS-C184632 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3532C6a

Anti-NCOA1 / SRC-1 Antibody (aa594-625) - LS-C161489 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SRC1 Antibody western blot of MDA-MB231 cell line lysates (35 ug/lane). The SRC1 antibody detected the SRC1 protein (arrow).

Anti-NCOA1 / SRC-1 Antibody (aa600-650) - LS-C287239 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunoprecipitation of SRC1. Samples: Nuclear extract (10 mg) from HeLa cells. Antibody: Affinity purified rabbit anti-SRC1 used at 20 ug/10 mg extract. Detection: Coomassie Brilliant Blue R250 staining of SDS-PAGE gel followed by mass spectrometry to confirm the identity of the band that is SRC1.

Anti-NCOA1 / SRC-1 Antibody (aa186-214) - LS-C100196 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of SRC1 (arrow) using rabbit polyclonal SRC1 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the SRC1 gene (Lane 2) (Origene Technologies).

Anti-NCOA1 / SRC-1 Antibody (aa611-660) - LS-C109852 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
NCOA1 antibody LS-C109852 Western blot of NCI-H226 cell lysate.
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