| Gene Symbol |
LTC4S
|
| Entrez Gene |
4056
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leukotriene C4 synthase
|
| Other Description |
LTC4 synthase
|
| Swissprots |
Q9UC73 Q9UD18 Q8N6P0 Q16873
|
| Accessions |
AAB06723 AAC50476 EAW53796 EAW53797 EAW53798 EAW53799 Q16873 AI480325 AK312033 BAG34970 BC029498 AAH29498 BI597970 BI819419 DQ890962 ABM81888 DQ894134 ABM85060 U09353 AAA20467 U11552 AAA50555 NM_145867 NP_665874
|
| Function |
Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
|
| Subcellular Location |
Nucleus outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Detected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells and platelets. {ECO:0000269|PubMed:7599836}.
|
| Top Pathways |
Arachidonic acid metabolism
|