Gene Symbol | LTC4S |
---|---|
Entrez Gene | 4056 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | leukotriene C4 synthase |
Other Description | LTC4 synthase |
Swissprots | Q9UC73 Q9UD18 Q8N6P0 Q16873 |
Accessions | AAB06723 AAC50476 EAW53796 EAW53797 EAW53798 EAW53799 Q16873 AI480325 AK312033 BAG34970 BC029498 AAH29498 BI597970 BI819419 DQ890962 ABM81888 DQ894134 ABM85060 U09353 AAA20467 U11552 AAA50555 NM_145867 NP_665874 |
Function | Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4. |
Subcellular Location | Nucleus outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. |
Tissue Specificity | Detected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells and platelets. {ECO:0000269|PubMed:7599836}. |
Top Pathways | Arachidonic acid metabolism |