Gene Symbol | LTC4S |
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Entrez Gene | 4056 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | leukotriene C4 synthase |
Other Description | LTC4 synthase |
Swissprots | Q9UC73 Q9UD18 Q8N6P0 Q16873 |
Accessions | AAB06723 AAC50476 EAW53796 EAW53797 EAW53798 EAW53799 Q16873 AI480325 AK312033 BAG34970 BC029498 AAH29498 BI597970 BI819419 DQ890962 ABM81888 DQ894134 ABM85060 U09353 AAA20467 U11552 AAA50555 NM_145867 NP_665874 |
Function | Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4. |
Subcellular Location | Nucleus outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. |
Tissue Specificity | Detected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells and platelets. {ECO:0000269|PubMed:7599836}. |
Top Pathways | Arachidonic acid metabolism |
LTC4 synthase CRISPR/Cas9 KO Plasmid (h) - sc-410874 from Santa Cruz Biotechnology
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LTC4 synthase HDR Plasmid (h) - sc-410874-HDR from Santa Cruz Biotechnology
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LTC4 synthase Double Nickase Plasmid (h) - sc-410874-NIC from Santa Cruz Biotechnology
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LTC4 synthase Double Nickase Plasmid (h2) - sc-410874-NIC-2 from Santa Cruz Biotechnology
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LTC4 synthase CRISPR Activation Plasmid (h) - sc-410874-ACT from Santa Cruz Biotechnology
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LTC4 synthase CRISPR Activation Plasmid (h2) - sc-410874-ACT-2 from Santa Cruz Biotechnology
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LTC4 synthase Lentiviral Activation Particles (h) - sc-410874-LAC from Santa Cruz Biotechnology
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LTC4 synthase Lentiviral Activation Particles (h2) - sc-410874-LAC-2 from Santa Cruz Biotechnology
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LTC 4 synthase siRNA (h) - sc-40727 from Santa Cruz Biotechnology
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LTC 4 synthase shRNA Plasmid (h) - sc-40727-SH from Santa Cruz Biotechnology
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LTC 4 synthase shRNA (h) Lentiviral Particles - sc-40727-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN12820 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12820 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04466 from Sigma-Aldrich
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LTC4S siRNA (Human) - CRH2745 from Cohesion Biosciences
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shRNA set against Human LTC4S (NM_145867.1) - SHH335523 from Creative biogene
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shRNA set against Human LTC4S(NM_145867.1) - SHH166289 from Creative biogene
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Human LTC4S siRNA - orb263247 from Biorbyt
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LTC4S shRNA Plasmid (Human) - CHH2745 from Cohesion Biosciences
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LTC4S miRNA 3'UTR clone - MiUTR1H-05954 from Creative biogene
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