PDE6D

Gene Symbol	PDE6D
Entrez Gene	5147
Alt Symbol	JBTS22, PDED
Species	Human
Gene Type	protein-coding
Description	phosphodiesterase 6D, cGMP-specific, rod, delta
Other Description	GMP-PDE delta|protein p17|retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Swissprots	O43250 O43924
Accessions	AAC25953 AAC39720 AAY24151 EAW70977 EAW70978 O43924 AF022912 AAB87872 AK311623 BC001054 BC007831 AAH07831 BC017467 BI754373 BT007278 AAP35942 CR456980 CAG33261 DQ893223 ABM84149 DQ896553 ABM87552 HY037751 XM_011511342 XP_011509644 NM_001291018 NP_001277947 NM_002601 NP_002592 NR_110994
Function	Promotes the release of prenylated target proteins from cellular membranes (PubMed:9712853). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22002721, PubMed:23698361). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (PubMed:24166846). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity). {ECO:0000250|UniProtKB:O55057, ECO:0000269|PubMed:10518933, ECO:0000269|PubMed:22002721, ECO:0000269|PubMed:23559067, ECO:0000269|PubMed:23698361, ECO:0000269|PubMed:24166846, ECO:0000269|PubMed:9712853}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:22002721, ECO:0000269|PubMed:23698361, ECO:0000269|PubMed:9712853}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9712853}; Peripheral membrane protein {ECO:0000269|PubMed:9712853}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24166846}.
Tissue Specificity	Widely expressed. Detected in various tissues including spleen, prostate gland, testis, ovary, small intestine, colon, retina, and peripheral blood. {ECO:0000269|PubMed:9712853}.
Top Pathways	Purine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PDE6D (A-8) - sc-376724 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

PDE6D (C-8) - sc-166855 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

PDE6D (E-7) - sc-166854 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

PDE6D (E-8) - sc-166836 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

PDE6D (FL-150) - sc-99220 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

PDE6D (N-15) - sc-50260 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

PDE6D (W-20) - sc-50262 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-PDE6 delta antibody - ab55563 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-PDE6 delta antibody - N-terminal - ab186947 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PDE6D / PDE6 Delta Antibody (aa25-55, APC) - LS-C265900 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PDE6D / PDE6 Delta Antibody (aa25-55, FITC) - LS-C265902 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PDE6D / PDE6 Delta Antibody (aa25-55, Biotin) - LS-C265901 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PDE6D / PDE6 Delta Antibody (aa25-55, Azide-free, HRP) - LS-C265903 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PDE6D / PDE6 Delta Antibody (aa25-55, PE) - LS-C265904 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PDE6D / PDE6 Delta Antibody (aa25-55) - LS-C329957 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PDE6D / PDE6 Delta Antibody (clone 4H6) - LS-C197861 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 4H6

Anti-PDE6D / PDE6 Delta Antibody (aa21-70) - LS-C206193 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PDE6D / PDE6 Delta Antibody (aa26-55) - LS-C158561 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-PDE6D / PDE6 Delta Antibody (aa1-150) - LS-C186054 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PDE6D / PDE6 Delta Antibody (aa25-55, AP) - LS-C265898 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

PDE6D Antibody - NBP1-32730 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

PDE6D Antibody (5C7) - H00005147-M06 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 5C7

PDE6D Antibody - NBP2-38346 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

PDE6D Antibody - NBP1-86275 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

PDE6D Antibody (4H6) - H00005147-M05 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 4H6

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