PDE6D

Gene Symbol PDE6D
Entrez Gene 5147
Alt Symbol JBTS22, PDED
Species Human
Gene Type protein-coding
Description phosphodiesterase 6D, cGMP-specific, rod, delta
Other Description GMP-PDE delta|protein p17|retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Swissprots O43250 O43924
Accessions AAC25953 AAC39720 AAY24151 EAW70977 EAW70978 O43924 AF022912 AAB87872 AK311623 BC001054 BC007831 AAH07831 BC017467 BI754373 BT007278 AAP35942 CR456980 CAG33261 DQ893223 ABM84149 DQ896553 ABM87552 HY037751 XM_011511342 XP_011509644 NM_001291018 NP_001277947 NM_002601 NP_002592 NR_110994
Function Promotes the release of prenylated target proteins from cellular membranes (PubMed:9712853). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22002721, PubMed:23698361). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (PubMed:24166846). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity). {ECO:0000250|UniProtKB:O55057, ECO:0000269|PubMed:10518933, ECO:0000269|PubMed:22002721, ECO:0000269|PubMed:23559067, ECO:0000269|PubMed:23698361, ECO:0000269|PubMed:24166846, ECO:0000269|PubMed:9712853}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:22002721, ECO:0000269|PubMed:23698361, ECO:0000269|PubMed:9712853}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9712853}; Peripheral membrane protein {ECO:0000269|PubMed:9712853}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24166846}.
Tissue Specificity Widely expressed. Detected in various tissues including spleen, prostate gland, testis, ovary, small intestine, colon, retina, and peripheral blood. {ECO:0000269|PubMed:9712853}.
Top Pathways Purine metabolism

PDE6D-Over-expression-Lysate - LY12958a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag PDE6D (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PDE6D gene

PDE6D 293 Cell Lysate - 409002 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

PDE6D Overexpression Lysate (Native) - NBL1-14228 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: PDE6D Overexpression Lysate (Adult Normal) [NBL1-14228] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PDE6D.

PDE6D Over-expression Lysate Product - GWB-FBE515 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human PDE6D Knockdown Stable Cell Line - CSC-DC011512 from Creative biogene

Category Cell Line
Species Human
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