PDE6D

Gene Symbol	PDE6D
Entrez Gene	5147
Alt Symbol	JBTS22, PDED
Species	Human
Gene Type	protein-coding
Description	phosphodiesterase 6D, cGMP-specific, rod, delta
Other Description	GMP-PDE delta|protein p17|retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Swissprots	O43250 O43924
Accessions	AAC25953 AAC39720 AAY24151 EAW70977 EAW70978 O43924 AF022912 AAB87872 AK311623 BC001054 BC007831 AAH07831 BC017467 BI754373 BT007278 AAP35942 CR456980 CAG33261 DQ893223 ABM84149 DQ896553 ABM87552 HY037751 XM_011511342 XP_011509644 NM_001291018 NP_001277947 NM_002601 NP_002592 NR_110994
Function	Promotes the release of prenylated target proteins from cellular membranes (PubMed:9712853). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22002721, PubMed:23698361). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (PubMed:24166846). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity). {ECO:0000250|UniProtKB:O55057, ECO:0000269|PubMed:10518933, ECO:0000269|PubMed:22002721, ECO:0000269|PubMed:23559067, ECO:0000269|PubMed:23698361, ECO:0000269|PubMed:24166846, ECO:0000269|PubMed:9712853}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:22002721, ECO:0000269|PubMed:23698361, ECO:0000269|PubMed:9712853}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9712853}; Peripheral membrane protein {ECO:0000269|PubMed:9712853}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24166846}.
Tissue Specificity	Widely expressed. Detected in various tissues including spleen, prostate gland, testis, ovary, small intestine, colon, retina, and peripheral blood. {ECO:0000269|PubMed:9712853}.
Top Pathways	Purine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PDE6 delta full length protein - ab40492 from Abcam Category Protein Source E. coli Species Human

Human PDE6 delta full length protein - ab117160 from Abcam Category Protein Source E. coli Species Human

PDE6 delta peptide - ab41788 from Abcam Category Peptide

PDE6D / PDE6 Delta Antibody Blocking Peptide - LS-E4986 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PDE6D Protein - H00005147-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PDE6D Protein - NBP1-44480 from Novus Biologicals Category Protein Prices $349.00 Sizes 100 µg Source E. coli Species Human

PDE6D-Antibody-Center-Blocking-Peptide - BP17384c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PDE6D Protein - GTX109240-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

PDE6D Protein (OPPA02164) - OPPA02164 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human Phosphodiesterase 6D cGMP-Specific Rod Delta protein - orb90209 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

PDE6D protein (His tag) - 80R-1317 from Fitzgerald Category Protein Prices $340.00 Sizes 100 µg Source E.coli

PDE6D / PDED (1-150, His-tag) - AR09463PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 500 µg Source E. coli Species Human

PDE6D / PDED (1-150, His-tag) - AR09463PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 100 µg Source E. coli Species Human

PDE6D / PDED - H00005147-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PDE6D / PDED - H00005147-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PDE6D / PDED control peptide - SP5249CP from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

PDE6D, 1-150aa, Human, His tag, E.coli - 01-1831 from ARP American Research Products Category Protein Prices $189.00, $449.00, $1,089.00 Sizes 20 µg, 50 µg, 500 µg Species Human

PDE6D Human - ENPS-490 from NeoScientific Category Protein Prices $65.00, $169.00, $4,680.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Retinal rod rhodopsin-sensitive cGMP 3\' 5\'-cyclic phosphodiesterase subunit delta - GWB-B0BCEB from Genway Biotech Category Protein Prices $185.00, $2,500.00 Sizes 50 µg, 1 mg

Recombinant Human Phosphodiesterase 6D cGMP-Specific Rod Delta - GWB-387D65 from Genway Biotech Category Protein Prices $75.00, $165.00, $4,035.00 Sizes 5 μg, 20 μg, 1000 μg Species Human

PDE6D, 1-150aa, Recombinant Protein - GWB-P1485C from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human PDE6D, His-tagged - PDE6D-2407H from Creative Biomart Category Protein Source E.coli.

Recombinant Human PDE6D, His-tagged - PDE6D-29160TH from Creative Biomart Category Protein Source E. coli

Recombinant Human PDE6D, T7 -tagged - PDE6D-30822TH from Creative Biomart Category Protein Source E. coli

PDE6D 1-150aa - CMB-386 from Reagent Proteins Category Protein Prices $539.00, $1,099.00 Sizes 100.00 µg, 500 µg Source E.coli Species Human

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