| Gene Symbol |
PDE6D
|
| Entrez Gene |
5147
|
| Alt Symbol |
JBTS22, PDED
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphodiesterase 6D, cGMP-specific, rod, delta
|
| Other Description |
GMP-PDE delta|protein p17|retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
|
| Swissprots |
O43250 O43924
|
| Accessions |
AAC25953 AAC39720 AAY24151 EAW70977 EAW70978 O43924 AF022912 AAB87872 AK311623 BC001054 BC007831 AAH07831 BC017467 BI754373 BT007278 AAP35942 CR456980 CAG33261 DQ893223 ABM84149 DQ896553 ABM87552 HY037751 XM_011511342 XP_011509644 NM_001291018 NP_001277947 NM_002601 NP_002592 NR_110994
|
| Function |
Promotes the release of prenylated target proteins from cellular membranes (PubMed:9712853). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22002721, PubMed:23698361). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (PubMed:24166846). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity). {ECO:0000250|UniProtKB:O55057, ECO:0000269|PubMed:10518933, ECO:0000269|PubMed:22002721, ECO:0000269|PubMed:23559067, ECO:0000269|PubMed:23698361, ECO:0000269|PubMed:24166846, ECO:0000269|PubMed:9712853}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:22002721, ECO:0000269|PubMed:23698361, ECO:0000269|PubMed:9712853}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9712853}; Peripheral membrane protein {ECO:0000269|PubMed:9712853}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24166846}.
|
| Tissue Specificity |
Widely expressed. Detected in various tissues including spleen, prostate gland, testis, ovary, small intestine, colon, retina, and peripheral blood. {ECO:0000269|PubMed:9712853}.
|
| Top Pathways |
Purine metabolism
|