PDE6D

Gene Symbol PDE6D
Entrez Gene 5147
Alt Symbol JBTS22, PDED
Species Human
Gene Type protein-coding
Description phosphodiesterase 6D, cGMP-specific, rod, delta
Other Description GMP-PDE delta|protein p17|retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Swissprots O43250 O43924
Accessions AAC25953 AAC39720 AAY24151 EAW70977 EAW70978 O43924 AF022912 AAB87872 AK311623 BC001054 BC007831 AAH07831 BC017467 BI754373 BT007278 AAP35942 CR456980 CAG33261 DQ893223 ABM84149 DQ896553 ABM87552 HY037751 XM_011511342 XP_011509644 NM_001291018 NP_001277947 NM_002601 NP_002592 NR_110994
Function Promotes the release of prenylated target proteins from cellular membranes (PubMed:9712853). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22002721, PubMed:23698361). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (PubMed:24166846). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity). {ECO:0000250|UniProtKB:O55057, ECO:0000269|PubMed:10518933, ECO:0000269|PubMed:22002721, ECO:0000269|PubMed:23559067, ECO:0000269|PubMed:23698361, ECO:0000269|PubMed:24166846, ECO:0000269|PubMed:9712853}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:22002721, ECO:0000269|PubMed:23698361, ECO:0000269|PubMed:9712853}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9712853}; Peripheral membrane protein {ECO:0000269|PubMed:9712853}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24166846}.
Tissue Specificity Widely expressed. Detected in various tissues including spleen, prostate gland, testis, ovary, small intestine, colon, retina, and peripheral blood. {ECO:0000269|PubMed:9712853}.
Top Pathways Purine metabolism

PDE6D CRISPR/Cas9 KO Plasmid (h) - sc-418288 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDE6D HDR Plasmid (h) - sc-418288-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDE6D Double Nickase Plasmid (h) - sc-418288-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDE6D Double Nickase Plasmid (h2) - sc-418288-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDE6D CRISPR Activation Plasmid (h) - sc-418288-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDE6D CRISPR Activation Plasmid (h2) - sc-418288-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDE6D Lentiviral Activation Particles (h) - sc-418288-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDE6D Lentiviral Activation Particles (h2) - sc-418288-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDE6D siRNA (h) - sc-61309 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PDE6D shRNA Plasmid (h) - sc-61309-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PDE6D shRNA (h) Lentiviral Particles - sc-61309-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PDE6D RNAi - H00005147-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU132211 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16542 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16542 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05219 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05219

PDE6D siRNA (Human) - CRH3427 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PDE6D (NM_002601.2) - SHH372536 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PDE6D(NM_002601.2) - SHR100710 from Creative biogene

Category siRNA
Species Reactivities Human

PDE6D shRNA Plasmid (Human) - CHH3427 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PDE6D miRNA 3'UTR clone - MiUTR1H-07716 from Creative biogene

Species Reactivities Human
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