CRYAB

Gene Symbol CRYAB
Entrez Gene 1410
Alt Symbol CMD1II, CRYA2, CTPP2, CTRCT16, HEL-S-101, HSPB5, MFM2
Species Human
Gene Type protein-coding
Description crystallin, alpha B
Other Description alpha-crystallin B chain|epididymis secretory protein Li 101|heat shock protein beta-5|heat-shock 20 kD like-protein|renal carcinoma antigen NY-REN-27|rosenthal fiber component
Swissprots Q9UC40 Q9UC37 P02511 Q9UC39 B0YIX0 O43416 Q9UC41 Q9UC38
Accessions AAA52104 ACA05949 EAW67162 EAW67163 EAW67164 EAW67165 EAW67166 EAW67167 P02511 AF007162 AAC19161 AK295498 BAG58418 AK314029 BAG36739 AM392549 CAL37427 AM393027 CAL37905 BC007008 AAH07008 BE076509 BF339748 BI548180 BI759672 BM721803 BT006770 AAP35416 DB506606 DQ892517 ABM83443 DQ895729 ABM86655 FJ224314 ACI46006 FJ876064 ACP18852 M24906 AAA60267 S45630 AAB23453 XM_011542608 XP_011540910 XM_011542609 XP_011540911 NM_001289807 NP_001276736 NM_001289808 NP_001276737 NM_001885 NP_001876
Function May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:19464326}. Nucleus {ECO:0000269|PubMed:19464326}. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
Tissue Specificity Lens as well as other tissues.
Top Pathways Protein processing in endoplasmic reticulum

CRYAB Antibody - 8851 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from SNB75 cells or human, mouse, and rat heart tissue using CRYAB Antibody.

αB-crystallin (A-4) - sc-365088 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
αB-crystallin (A-4): sc-365088. Western blot analysis of αB-crystallin expression in non-transfected: sc-117752 (A) and mouse αB-crystallin transfected: sc-118149 (B) 293T whole cell lysates.

αB-crystallin (A-7) - sc-137143 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
αB-crystallin (A-7): sc-137143. Western blot analysis of αB-crystallin expression in non-transfected: sc-117752 (A) and mouse αB-crystallin transfected: sc-118149 (B) 293T whole cell lysates.

αB-crystallin (C-5) - sc-398079 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
αB-crystallin (C-5): sc-398079. Western blot analysis of αB-crystallin expression in non-transfected 293T: sc-117752 (A), mouse αB-crystallin transfected 293T: sc-118149 (B) and Y79 (E) whole cell lysates and rat heart (C) and human heart (D) tissue extracts.

αB-crystallin (C-8) - sc-137144 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
αB-crystallin (C-8): sc-137144. Western blot analysis of αB-crystallin expression in non-transfected: sc-117752 (A) and mouse αB-crystallin transfected: sc-118149 (B) 293T whole cell lysates.

αB-crystallin (F-10) - sc-137129 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
αB-crystallin (F-10): sc-137129. Western blot analysis of αB-crystallin expression in non-transfected: sc-117752 (A) and mouse αB-crystallin transfected: sc-118149 (B) 293T whole cell lysates.

αB-crystallin (FL-175) - sc-22744 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
αB-crystallin (FL-175): sc-22744. Western blot analysis of αB-crystallin expression in mouse eye (A) and rat eye (B) tissue extracts.

αB-crystallin (K-20) - sc-22391 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
αB-crystallin (K-20): sc-22391. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic staining of myocytes.

p-αB-crystallin (F-1) - sc-365884 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of αB-crystallin phosphorylation in untreated (A,C) and lambda protein phosphatase (sc-200312A) treated (B,D) rat kidney tissue extracts. Antibodies tested include p-αB-crystallin (F-1): sc-365884 (A,B) and αB-crystallin (F-10): sc-137129 (C,D).

Anti-alpha B Crystallin (phospho S19) antibody - ab61028 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded human skeletal muscle tissue using ab61028 at 1/50 dilution. Samples were treated -/+ immunising peptide.

Anti-alpha B Crystallin (phospho S45) antibody - ab62254 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab62254 at 1/50 - 1/100 dilution staining alpha B Crystallin in Human heart by Immunohistochemistry, Paraffin-embedded tissue, in the absence or presence of the immunising peptide.

Anti-Alpha B Crystallin (phospho S59) antibody - ab103282 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Alpha B Crystallin (phospho S59) antibody (ab103282) at 1 µg/mlLane 1 : Spinal Cord (Human) Tissue Lysate - adult normal tissue (ab29188)Lane 2 : Spinal Cord (Human) Tissue Lysate - adult normal tissue (ab29188) with Immunising peptide at 1 µg/mlLane 3 : Spinal Cord (Human) Tissue Lysate - adult normal tissue (ab29188) with Non modified peptide at 1 µg/mlLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-alpha B Crystallin (phospho S59) antibody - ab61038 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
1/50-1/100 ab61038 staining phosphorilated alpha B Crystallin in human skeletal muscle tissue, in the absence or presence of the immunizing phosphopeptide.

Anti-alpha B Crystallin antibody - ab61140 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab61140 at 1/50 dilution staining human skeletal muscle without (left) and with (right) blocking peptide; paraffin embedded.

Anti-alpha B Crystallin antibody - ab61141 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab61141 at 1/50 dilution staining human skeletal muscle without (left) and with (right) blocking peptide.

Anti-alpha B Crystallin antibody - ab62690 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab62690 at 1/50 - 1/100 dilution staining alpha B Crystallin in human heart by Immunohistochemistry, Paraffin-embedded tissue, in the absence or presence of the immunising peptide.

Anti-Alpha B Crystallin antibody - ab116563 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Alpha B Crystallin antibody (ab116563) at 1/100 dilutionLane 1 : 293 cell lysate Lane 2 : 293 cell (transiently transfected with the CRYAB gene) lysate Lysates/proteins at 2 µg per lane.

Anti-Alpha B Crystallin antibody [3E3] - ab118004 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3E3
All lanes : Anti-Alpha B Crystallin antibody [3E3] (ab118004) at 1/2000 dilutionLane 1 : HEK293T lysate transfected with pCMV6-ENTRY control cDNA for 48 hrs Lane 2 : HEK293T lysate transfected with pCMV6-ENTRY Aplha B Crystallin cDNA for 48 hrs Lysates/proteins at 5 µg per lane.

Anti-Alpha B Crystallin antibody [EPR2751Y] - ab75833 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2751Y
Anti-Alpha B Crystallin antibody [EPR2751Y] (ab75833) at 1/2000 dilution + human heart cell lysate at 10 µgSecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Alpha B Crystallin antibody [EPR2752] - ab76467 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2752
Immunohistochemical staining of paraffin embedded human brain with purified ab76467 at a working dilution of 1 in 250. The secondary antibody used is a HRP polymer for rabbit IgG. The sample is counter-stained with hematoxylin. Antigen retrieval was perfomed using Tris-EDTA buffer, pH 9.0.

Anti-CRYAB / Alpha B Crystallin Antibody (clone 4A6) - LS-C114679 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 4A6
IHC of paraffin-embedded endometrium tissue using anti-CRYAB mouse monoclonal antibody. (Dilution 1:50).

Anti-CRYAB / Alpha B Crystallin Antibody IHC-plus™ - LS-B3696 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-CRYAB / Alpha B Crystallin antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3696 concentration 10 ug/ml.

Anti-CRYAB / Alpha B Crystallin Antibody (clone 3C2) - LS-C114670 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 3C2
IHC of paraffin-embedded Adenocarcinoma of ovary tissue using anti-CRYAB mouse monoclonal antibody. (Dilution 1:50).

Anti-CRYAB / Alpha B Crystallin Antibody (clone 1A7.D5) IHC-plus™ - LS-B7449 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 1A7.D5
Anti-CRYAB / Alpha B Crystallin antibody IHC of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7449 concentration 20 ug/ml.

Anti-CRYAB / Alpha B Crystallin Antibody (clone 3A10.H4) IHC-plus™ - LS-B7454 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 3A10.H4
Anti-CRYAB / Alpha B Crystallin antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7454 concentration 10 ug/ml.
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