PIK3AP1

Gene Symbol	PIK3AP1
Entrez Gene	118788
Alt Symbol	BCAP
Species	Human
Gene Type	protein-coding
Description	phosphoinositide-3-kinase adaptor protein 1
Other Description	B cell adaptor protein|B-cell adapter for phosphoinositide 3-kinase|B-cell phosphoinositide 3-kinase adapter protein 1|phosphoinositide 3-kinase adapter protein 1
Swissprots	Q8NAC8 Q8N6J6 Q5VXJ9 Q5TB56 Q6ZUJ8
Accessions	CCQ77684 EAW49968 EAW49969 Q6ZUJ8 AI826732 AK092883 BAC03996 AK122584 BAC56925 AK125635 BAC86227 AM393069 CAL37947 BC029917 AAH29917 BX648550 CB990570 XM_005269498 XP_005269555 XM_005269499 XP_005269556 XM_011539248 XP_011537550 XM_011539249 XP_011537551 NM_152309 NP_689522
Function	Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}.
Subcellular Location	Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity	Expressed in natural killer (NK) cells. {ECO:0000269|PubMed:18337558}.
Top Pathways	B cell receptor signaling pathway, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

BCAP (E-12) - sc-133360 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

BCAP (K-14) - sc-133361 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

BCAP (T-12) - sc-133362 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

BCAP (S-15)-R - sc-30601-R from Santa Cruz Biotechnology Prices $61.00 Sizes 100 µg/0.5 ml Host Rabbit Clonality Polyclonal

BCAP (T-20) - sc-30600 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-PIK3AP1 antibody [7B12] - ab124031 from Abcam Prices $370.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 7B12

Anti-PIK3AP1 antibody - N-terminal - ab157151 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-BCAP / PIK3AP1 Antibody (clone 7A12) - LS-C172394 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 7A12

Anti-BCAP / PIK3AP1 Antibody (aa397-650) - LS-C295895 from LifeSpan Bioscience Prices $425.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BCAP / PIK3AP1 Antibody (clone 5A5) - LS-C175782 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 5A5

Anti-BCAP / PIK3AP1 Antibody (clone 5A1) - LS-C175784 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 5A1

Anti-BCAP / PIK3AP1 Antibody (clone 5H2) - LS-C175787 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 5H2

Anti-BCAP / PIK3AP1 Antibody (clone 5H5) - LS-C175783 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 5H5

Anti-BCAP / PIK3AP1 Antibody (clone 7B12) - LS-C175785 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 7B12

Anti-BCAP / PIK3AP1 Antibody (clone 6H6) - LS-C175788 from LifeSpan Bioscience Prices $350.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 6H6

Anti-BCAP / PIK3AP1 Antibody (clone 7A11) - LS-C175789 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 7A11

Anti-BCAP / PIK3AP1 Antibody (clone 7G9) - LS-C175786 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 7G9

Anti-BCAP / PIK3AP1 Antibody (aa639-668, AP) - LS-C239041 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BCAP / PIK3AP1 Antibody (aa639-668, APC) - LS-C239042 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BCAP / PIK3AP1 Antibody (aa639-668, Biotin) - LS-C239043 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BCAP / PIK3AP1 Antibody (aa639-668) - LS-C163724 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-BCAP / PIK3AP1 Antibody (aa639-668, FITC) - LS-C239044 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BCAP / PIK3AP1 Antibody (aa639-668, PE) - LS-C239045 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BCAP / PIK3AP1 Antibody (aa639-668, Azide-free, HRP) - LS-C248474 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BCAP / PIK3AP1 Antibody (aa397-650, Biotin) - LS-C301016 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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