| Gene Symbol |
PIK3AP1
|
| Entrez Gene |
118788
|
| Alt Symbol |
BCAP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphoinositide-3-kinase adaptor protein 1
|
| Other Description |
B cell adaptor protein|B-cell adapter for phosphoinositide 3-kinase|B-cell phosphoinositide 3-kinase adapter protein 1|phosphoinositide 3-kinase adapter protein 1
|
| Swissprots |
Q8NAC8 Q8N6J6 Q5VXJ9 Q5TB56 Q6ZUJ8
|
| Accessions |
CCQ77684 EAW49968 EAW49969 Q6ZUJ8 AI826732 AK092883 BAC03996 AK122584 BAC56925 AK125635 BAC86227 AM393069 CAL37947 BC029917 AAH29917 BX648550 CB990570 XM_005269498 XP_005269555 XM_005269499 XP_005269556 XM_011539248 XP_011537550 XM_011539249 XP_011537551 NM_152309 NP_689522
|
| Function |
Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Expressed in natural killer (NK) cells. {ECO:0000269|PubMed:18337558}.
|
| Top Pathways |
B cell receptor signaling pathway, PI3K-Akt signaling pathway
|