PIK3AP1

Gene Symbol	PIK3AP1
Entrez Gene	118788
Alt Symbol	BCAP
Species	Human
Gene Type	protein-coding
Description	phosphoinositide-3-kinase adaptor protein 1
Other Description	B cell adaptor protein|B-cell adapter for phosphoinositide 3-kinase|B-cell phosphoinositide 3-kinase adapter protein 1|phosphoinositide 3-kinase adapter protein 1
Swissprots	Q8NAC8 Q8N6J6 Q5VXJ9 Q5TB56 Q6ZUJ8
Accessions	CCQ77684 EAW49968 EAW49969 Q6ZUJ8 AI826732 AK092883 BAC03996 AK122584 BAC56925 AK125635 BAC86227 AM393069 CAL37947 BC029917 AAH29917 BX648550 CB990570 XM_005269498 XP_005269555 XM_005269499 XP_005269556 XM_011539248 XP_011537550 XM_011539249 XP_011537551 NM_152309 NP_689522
Function	Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}.
Subcellular Location	Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity	Expressed in natural killer (NK) cells. {ECO:0000269|PubMed:18337558}.
Top Pathways	B cell receptor signaling pathway, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Phosphoinositide 3-kinase adapter protein 1 (PIK3AP1), Human, ELISA Kit - CSB-EL017993HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Phosphoinositide 3-kinase adapter protein 1, ELISA Kit - MBS280390 from MyBioSource Category ELISA Kit Prices $425.00, $720.00, $3,160.00, $6,055.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

phosphoinositide-3-kinase adaptor protein 1, ELISA Kit - MBS921634 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human PIK3AP1 is typically less than 5.86 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 23.5 pg/ml -1500 pg/ml.

Human Phosphoinositide 3-kinase adapter protein 1(PIK3AP1) ELISA kit - CSB-EL017993HU from Cusabio Category ELISA Kit Sensitivity 5.86pg/ml Range 23.5 pg/ml-1500 pg/ml

Human PIK3AP1 ELISA Kit - E029115 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human PIK3AP1 is typically less than 5.86 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the

PIK3AP1 ELISA Kit (Human) (OKCA01421) - OKCA01421 from Aviva Systems Biology Category ELISA Kit Prices $600.00 Sizes 96 wells Sensitivity 5.86 pg/mL Range 23.5 - 1,500 pg/mL

Human PIK3AP1 ELISA Kit - orb405014 from Biorbyt Category ELISA Kit Sensitivity 5.86pg/ml Range 23.5 pg/ml-1500 pg/ml

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