PIK3AP1

Gene Symbol PIK3AP1
Entrez Gene 118788
Alt Symbol BCAP
Species Human
Gene Type protein-coding
Description phosphoinositide-3-kinase adaptor protein 1
Other Description B cell adaptor protein|B-cell adapter for phosphoinositide 3-kinase|B-cell phosphoinositide 3-kinase adapter protein 1|phosphoinositide 3-kinase adapter protein 1
Swissprots Q8NAC8 Q8N6J6 Q5VXJ9 Q5TB56 Q6ZUJ8
Accessions CCQ77684 EAW49968 EAW49969 Q6ZUJ8 AI826732 AK092883 BAC03996 AK122584 BAC56925 AK125635 BAC86227 AM393069 CAL37947 BC029917 AAH29917 BX648550 CB990570 XM_005269498 XP_005269555 XM_005269499 XP_005269556 XM_011539248 XP_011537550 XM_011539249 XP_011537551 NM_152309 NP_689522
Function Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity Expressed in natural killer (NK) cells. {ECO:0000269|PubMed:18337558}.
Top Pathways B cell receptor signaling pathway, PI3K-Akt signaling pathway

BCAP CRISPR/Cas9 KO Plasmid (h) - sc-404405 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BCAP HDR Plasmid (h) - sc-404405-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BCAP Double Nickase Plasmid (h) - sc-404405-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BCAP Double Nickase Plasmid (h2) - sc-404405-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BCAP CRISPR Activation Plasmid (h) - sc-404405-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BCAP CRISPR Activation Plasmid (h2) - sc-404405-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BCAP Lentiviral Activation Particles (h) - sc-404405-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BCAP Lentiviral Activation Particles (h2) - sc-404405-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BCAP siRNA (h) - sc-44681 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BCAP shRNA Plasmid (h) - sc-44681-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BCAP shRNA (h) Lentiviral Particles - sc-44681-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BCAP/PIK3AP1 RNAi - H00118788-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU080441 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16806 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16806 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11196 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11196

PIK3AP1 siRNA (Human) - CRJ4596 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PIK3AP1 (NM_152309.2) - SHH375652 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PIK3AP1(NM_152309.2) - SHR104664 from Creative biogene

Category siRNA
Species Reactivities Human

Human PIK3AP1 siRNA - orb275097 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PIK3AP1 shRNA Plasmid (Human) - CHJ4596 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PIK3AP1 miRNA 3'UTR clone - MiUTR1H-07902 from Creative biogene

Species Reactivities Human
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