FBXO6

Gene Symbol	FBXO6
Entrez Gene	26270
Alt Symbol	FBG2, FBS2, FBX6, Fbx6b
Species	Human
Gene Type	protein-coding
Description	F-box protein 6
Other Description	F-box only protein 6|F-box protein FBG2|F-box protein Fbx6|F-box protein that recognizes sugar chains 2|F-box/G-domain protein 2
Swissprots	B2RC88 Q9UKT3 B1AK42 Q9NRD1
Accessions	EAW71696 Q9NRD1 AF129536 AAF04470 AF233223 AAF67153 AK314989 BAG37485 BC020880 AAH20880 HQ447671 ADQ32156 XM_005263448 XP_005263505 XM_005263449 XP_005263506 XM_005263451 XP_005263508 XM_006710571 XP_006710634 XM_011541232 XP_011539534 NM_018438 NP_060908
Function	Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex- type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication. {ECO:0000269|PubMed:18203720, ECO:0000269|PubMed:19716789}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:19716789}.
Top Pathways	Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

FBXO6 (C-20) - sc-323856 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

FBXO6 (L-15) - sc-323855 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

FBXO6 (S-17) - sc-101870 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

FBXO6 (7B11) - sc-134339 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

FBXO6/44 (H-51) - sc-99108 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-FbxO6 antibody - ab153853 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-FbxO6 antibody - ab103635 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-FbxO6 antibody - ab57058 from Abcam Host Mouse Clonality Monoclonal

Anti-FbxO6 antibody - ab172492 from Abcam Prices $370.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Anti-FBXO6 Antibody (aa268-284) - LS-C40725 from LifeSpan Bioscience Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-FBXO6 Antibody (aa280-293) - LS-C54828 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-FBXO6 Antibody (aa268-284) - LS-C83757 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-FBXO6 Antibody - LS-C307983 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-FBXO6 Antibody - LS-C310342 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-FBXO6 Antibody - LS-C153065 from LifeSpan Bioscience Prices $365.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

FBXO6 Antibody - NBP2-16451 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

FBXO6 Antibody - H00026270-D01P from Novus Biologicals Prices $399.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

FBXO6 Antibody (3F10) - H00026270-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3F10

FBXO6 Antibody - NB100-93568 from Novus Biologicals Prices $229.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

FBXO6 Antibody - NBP2-14012 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

FBXO6 Antibody - H00026270-B01 from Novus Biologicals Prices $349.00 Sizes 50 µl Host Mouse Clonality Polyclonal

FBXO6 Antibody (7D1) - H00026270-M02A from Novus Biologicals Prices $349.00 Sizes 200 µl Host Mouse Clonality Monoclonal Clone 7D1

FBXO6 Antibody - NB100-1299 from Novus Biologicals Prices $229.00 Sizes 100 µg Host Goat Clonality Polyclonal

Rabbit Anti-FbxO6 Polyclonal Antibody - bs-6415R from Bioss Host Rabbit Clonality Polyclonal

Monoclonal Anti-FBXO6 antibody produced in mouse - WH0026270M1 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3F10

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