FBXO6

Gene Symbol	FBXO6
Entrez Gene	26270
Alt Symbol	FBG2, FBS2, FBX6, Fbx6b
Species	Human
Gene Type	protein-coding
Description	F-box protein 6
Other Description	F-box only protein 6|F-box protein FBG2|F-box protein Fbx6|F-box protein that recognizes sugar chains 2|F-box/G-domain protein 2
Swissprots	B2RC88 Q9UKT3 B1AK42 Q9NRD1
Accessions	EAW71696 Q9NRD1 AF129536 AAF04470 AF233223 AAF67153 AK314989 BAG37485 BC020880 AAH20880 HQ447671 ADQ32156 XM_005263448 XP_005263505 XM_005263449 XP_005263506 XM_005263451 XP_005263508 XM_006710571 XP_006710634 XM_011541232 XP_011539534 NM_018438 NP_060908
Function	Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex- type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication. {ECO:0000269|PubMed:18203720, ECO:0000269|PubMed:19716789}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:19716789}.
Top Pathways	Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

FBXO6 293T Cell Transient Overexpression Lysate(Denatured) - H00026270-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

FBXO6 overexpression lysate - LY412992 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

FBXO6 293 Cell Lysate - 406304 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

FBXO6 Overexpression Lysate (Denatured) - H00026270-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

FBXO6 Overexpression Lysate (Native) - NBL1-10640 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

FBXO6 Over-expression Lysate Product - GWB-802D49 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human FBXO6 Knockdown Stable Cell Line - CSC-DC005617 from Creative biogene Category Cell Line Species Human

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