FBXO6

Gene Symbol FBXO6
Entrez Gene 26270
Alt Symbol FBG2, FBS2, FBX6, Fbx6b
Species Human
Gene Type protein-coding
Description F-box protein 6
Other Description F-box only protein 6|F-box protein FBG2|F-box protein Fbx6|F-box protein that recognizes sugar chains 2|F-box/G-domain protein 2
Swissprots B2RC88 Q9UKT3 B1AK42 Q9NRD1
Accessions EAW71696 Q9NRD1 AF129536 AAF04470 AF233223 AAF67153 AK314989 BAG37485 BC020880 AAH20880 HQ447671 ADQ32156 XM_005263448 XP_005263505 XM_005263449 XP_005263506 XM_005263451 XP_005263508 XM_006710571 XP_006710634 XM_011541232 XP_011539534 NM_018438 NP_060908
Function Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex- type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication. {ECO:0000269|PubMed:18203720, ECO:0000269|PubMed:19716789}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:19716789}.
Top Pathways Protein processing in endoplasmic reticulum

FBXO6 CRISPR/Cas9 KO Plasmid (h) - sc-405919 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBXO6 HDR Plasmid (h) - sc-405919-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBXO6 Double Nickase Plasmid (h) - sc-405919-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBXO6 Double Nickase Plasmid (h2) - sc-405919-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBXO6 CRISPR Activation Plasmid (h) - sc-405919-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBXO6 CRISPR Activation Plasmid (h2) - sc-405919-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBXO6 Lentiviral Activation Particles (h) - sc-405919-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBXO6 Lentiviral Activation Particles (h2) - sc-405919-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBXO6 siRNA (h) - sc-88674 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FBXO6 shRNA Plasmid (h) - sc-88674-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FBXO6 shRNA (h) Lentiviral Particles - sc-88674-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FBXO6 RNAi - H00026270-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU030491 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8566 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8566 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04393 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04393

FBXO6 siRNA (Human) - CRH8793 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FBXO6 - MBS8230457 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FBXO6 (NM_018438.5) - SHH293405 from Creative biogene

Category siRNA
Species Reactivities Human

Human FBXO6 siRNA - orb269295 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FBXO6 shRNA Plasmid (Human) - CHH8793 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FBXO6 miRNA 3'UTR clone - MiUTR3H-07853 from Creative biogene

Species Reactivities Human
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