FBXO6

Gene Symbol FBXO6
Entrez Gene 26270
Alt Symbol FBG2, FBS2, FBX6, Fbx6b
Species Human
Gene Type protein-coding
Description F-box protein 6
Other Description F-box only protein 6|F-box protein FBG2|F-box protein Fbx6|F-box protein that recognizes sugar chains 2|F-box/G-domain protein 2
Swissprots B2RC88 Q9UKT3 B1AK42 Q9NRD1
Accessions EAW71696 Q9NRD1 AF129536 AAF04470 AF233223 AAF67153 AK314989 BAG37485 BC020880 AAH20880 HQ447671 ADQ32156 XM_005263448 XP_005263505 XM_005263449 XP_005263506 XM_005263451 XP_005263508 XM_006710571 XP_006710634 XM_011541232 XP_011539534 NM_018438 NP_060908
Function Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex- type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication. {ECO:0000269|PubMed:18203720, ECO:0000269|PubMed:19716789}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:19716789}.
Top Pathways Protein processing in endoplasmic reticulum

F-box only protein 6 (FBXO6), Human, ELISA Kit - E01F0307 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

FBXO6 (Human) IP-WB Antibody Pair - H00026270-PW1 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

FBXO6 (Human) IP-WB Antibody Pair - H00026270-PW2 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

FBXO6 (Human) Matched Antibody Pair - H00026270-AP11 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

F box only protein 6 (FBXO6), ELISA Kit - MBS7209418 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

F-box only protein 6 (FBXO6), ELISA Kit - MBS7206672 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

F-box only protein 6 (FBXO6), ELISA Kit - MBS7232550 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

F-box only protein 6 (FBXO6), ELISA Kit - MBS7235640 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

F-box only protein 6 (FBXO6), ELISA Kit - MBS7209536 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

F-box only protein 6 (FBXO6), ELISA Kit - MBS7225419 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

F-box only protein 6 (FBXO6), ELISA Kit - MBS7249483 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

F-box only protein 6 (FBXO6), ELISA Kit - MBS7235429 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

F-box only protein 6 (FBXO6), ELISA Kit - MBS7244674 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

F-box only protein 6 (FBXO6), ELISA Kit - MBS7247779 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

F-box only protein 6 (FBXO6), ELISA Kit - MBS7234262 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

F-box only protein 6 (FBXO6), ELISA Kit - MBS7208168 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human FBXO6 ELISA Kit - E013974 from Biobool

Category ELISA Kit
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