FBXO6

Gene Symbol	FBXO6
Entrez Gene	26270
Alt Symbol	FBG2, FBS2, FBX6, Fbx6b
Species	Human
Gene Type	protein-coding
Description	F-box protein 6
Other Description	F-box only protein 6|F-box protein FBG2|F-box protein Fbx6|F-box protein that recognizes sugar chains 2|F-box/G-domain protein 2
Swissprots	B2RC88 Q9UKT3 B1AK42 Q9NRD1
Accessions	EAW71696 Q9NRD1 AF129536 AAF04470 AF233223 AAF67153 AK314989 BAG37485 BC020880 AAH20880 HQ447671 ADQ32156 XM_005263448 XP_005263505 XM_005263449 XP_005263506 XM_005263451 XP_005263508 XM_006710571 XP_006710634 XM_011541232 XP_011539534 NM_018438 NP_060908
Function	Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex- type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication. {ECO:0000269|PubMed:18203720, ECO:0000269|PubMed:19716789}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:19716789}.
Top Pathways	Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FbxO6 full length protein - ab161959 from Abcam Category Protein Source Wheat germ Species Human

Human FbxO6 full length protein - ab167876 from Abcam Category Protein Source E. coli Species Human

Human FbxO6 peptide - ab23100 from Abcam Category Peptide Species Human

FBXO6 Antibody Blocking Peptide - LS-E25586 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FBXO6 Recombinant Protein - H00026270-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 10 ug 25 ug Species Human

Recombinant Human FBXO6 Protein - NBP2-23042 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

FBXO6 blocking peptide - GTX25307-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Human FBXO6 protein - orb191299 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

FBXO6 protein (His tag) - 80R-2873 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

fbxO6 Peptide - AC21-0415-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

FBXO6 (1-293, His-tag) - AR50992PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

FBXO6 (1-293, His-tag) - AR50992PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

FBXO6 - H00026270-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

FBXO6, 1-293aa, Human, His tag, E.coli - 01-P2168 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

FBXO6 Peptide - 45-582P from ProSci Category Peptide Prices $175.00 Sizes 100 µg

FBXO6 fusion protein - Ag2400 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human FBXO6, GST-tagged - FBXO6-12804H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human F-box protein 6, His-tagged - FBXO6-214H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human F-box only protein 6(FBXO6) - CSB-YP873634HU CSB-EP873634HU CSB-BP873634HU CSB-MP873634HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

FBXO6, 1-293aa, Human, His tag, E.coli (Denatured) - ATGP2168 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

FBXO6 - TP305063 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

FBXO6, Peptide - MBS425910 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

FBXO6 Recombinant Protein Antigen - NBP2-14012PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

FBXO6 Peptide, Human - M34GP05617H from Creative Peptides Category Peptide Source Synthetic. Species Human

F-box only protein 6 (FBXO6), Recombinant Protein - MBS1299555 from MyBioSource Category Protein Prices $1,050.00, $1,050.00, $1,280.00, $1,280.00, $1,630.00, $1,630.00, $2,095.00, $2,095.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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