| Gene Symbol |
RFK
|
| Entrez Gene |
55312
|
| Alt Symbol |
RIFK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
riboflavin kinase
|
| Other Description |
0610038L10Rik|ATP:riboflavin 5'-phosphotransferase|flavokinase
|
| Swissprots |
Q969G6 Q9NUT7 Q5JSG9
|
| Accessions |
EAW62578 EAW62579 Q969G6 AF038172 AK002011 BAA92033 AK123933 AK307079 AK315734 BAG38089 BC007069 AAH07069 BF979572 DA154523 DB499473 DB531307 NM_018339 NP_060809
|
| Function |
Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase. {ECO:0000269|PubMed:19641494}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Detected in brain, placenta and urinary bladder.
|
| Top Pathways |
Riboflavin metabolism
|
![Western Blot: RFK Overexpression Lysate (Adult Normal) [NBL1-15297] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RFK.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7685_RFK%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15297-img0002.jpg)