RFK

Gene Symbol	RFK
Entrez Gene	55312
Alt Symbol	RIFK
Species	Human
Gene Type	protein-coding
Description	riboflavin kinase
Other Description	0610038L10Rik|ATP:riboflavin 5'-phosphotransferase|flavokinase
Swissprots	Q969G6 Q9NUT7 Q5JSG9
Accessions	EAW62578 EAW62579 Q969G6 AF038172 AK002011 BAA92033 AK123933 AK307079 AK315734 BAG38089 BC007069 AAH07069 BF979572 DA154523 DB499473 DB531307 NM_018339 NP_060809
Function	Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase. {ECO:0000269|PubMed:19641494}.
Subcellular Location	Cytoplasm {ECO:0000250}.
Tissue Specificity	Detected in brain, placenta and urinary bladder.
Top Pathways	Riboflavin metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Riboflavin kinase CRISPR/Cas9 KO Plasmid (h) - sc-418359 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Riboflavin kinase HDR Plasmid (h) - sc-418359-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Riboflavin kinase Double Nickase Plasmid (h) - sc-418359-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Riboflavin kinase Double Nickase Plasmid (h2) - sc-418359-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Riboflavin kinase CRISPR Activation Plasmid (h) - sc-418359-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Riboflavin kinase CRISPR Activation Plasmid (h2) - sc-418359-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Riboflavin kinase Lentiviral Activation Particles (h) - sc-418359-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Riboflavin kinase Lentiviral Activation Particles (h2) - sc-418359-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Riboflavin kinase siRNA (h) - sc-62940 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Riboflavin kinase shRNA Plasmid (h) - sc-62940-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Riboflavin kinase shRNA (h) Lentiviral Particles - sc-62940-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU025921 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU111551 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1949 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1948 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1947 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN18171 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18171 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10500 from Sigma-Aldrich Category miRNA

RFK siRNA (Human) - CRJ0645 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

RFK RNAi - H00055312-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

RFK - MBS8202707 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human RFK (NM_018339.5) - SHH392265 from Creative biogene Category siRNA Species Reactivities Human

Human RFK siRNA - orb271146 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

RFK shRNA Plasmid (Human) - CHJ0645 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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