XPO5

Gene Symbol	XPO5
Entrez Gene	57510
Alt Symbol	exp5
Species	Human
Gene Type	protein-coding
Description	exportin 5
Other Description	exportin-5|ran-binding protein 21
Swissprots	Q9NT89 Q9HAV4 Q9BZV5 Q9ULC9 Q96G48 Q5JTE6 Q96HN3 Q9BWM6 Q9H9M4 Q9NW39
Accessions	EAX04206 EAX04207 Q9HAV4 AB033117 BAA86605 AF271159 AAG53603 AF298880 AAG17907 AK001195 BAA91547 AK022718 BAB14200 AK023431 BAB14572 AK024301 BAG51288 AK025864 AK056619 BAG51767 AK127513 AK291452 BAF84141 AL137467 CAB70753 AL834207 BC000129 AAH00129 BC008347 AAH08347 BC009969 AAH09969 BC062635 AAH62635 BF108994 DB068849 NM_020750 NP_065801
Function	Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-media
Subcellular Location	Nucleus {ECO:0000269|PubMed:11777942}. Cytoplasm {ECO:0000269|PubMed:11777942}. Note=Shuttles between the nucleus and the cytoplasm.
Tissue Specificity	Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:11777942}.
Top Pathways	RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human XPO5 / Exportin 5 ELISA Kit (Sandwich ELISA) - LS-F7542 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.115 ng/ml Range 0.313-20 ng/ml

Human Exportin 5 ELISA Kit - abx151460 from Abbexa Category ELISA Kit Sensitivity 0.115 ng/ml Range 0.313 ng/ml - 20 ng/ml

Exportin 5 (XPO5), Human, ELISA Kit - SEF160Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.115ng/mL Range 0.312-20ng/mL

XPO5 (Human) IP-WB Antibody Pair - H00057510-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Exportin 5, ELISA Kit - MBS047878 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exportin 5, ELISA Kit - MBS069988 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exportin 5, ELISA Kit - MBS106107 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exportin 5, ELISA Kit - MBS061317 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exportin 5, ELISA Kit - MBS056469 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exportin 5, ELISA Kit - MBS063386 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exportin 5, ELISA Kit - MBS084721 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exportin 5 (XPO5), ELISA Kit - MBS2024227 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human XPO5 is typically less than 0.115ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 0.312-20ng/mL

ELISA Kit for Exportin 5 (XPO5) - SEF160Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.115ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Exportin 5 (XPO5) - SEF160Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.115ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human Exportin 5 (XPO5) ELISA Kit - EKU04001 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.115 ng/mL Range 0.312-20 ng/mL

Exportin 5 (XPO5), Human, ELISA Kit - DL-XPO5-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.312-20 ng/mL

Human XPO5 ELISA Kit - abx572582 from Abbexa Category ELISA Kit Sensitivity 0.115 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human XPO5 ELISA Kit - E013869 from Biobool Category ELISA Kit

XPO5 ELISA Kit (Human) (OKCD00958) - OKCD00958 from Aviva Systems Biology Category ELISA Kit Prices $545.00 Sizes 96 wells Sensitivity < 0.115 ng/mL Range 0.312-20 ng/mL

Human Exportin-5 (XPO5) ELISA Kit - AE11002HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.115 ng/mL Range 0.312-20 ng/mL

Exportin 5 (XPO5), ELISA Kit - MBS450929 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.115ng/mL Range 0.312-20ng/mL

Exportin 5 (XPO5), ELISA Kit - MBS9376758 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Search more