| Gene Symbol |
XPO5
|
| Entrez Gene |
57510
|
| Alt Symbol |
exp5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
exportin 5
|
| Other Description |
exportin-5|ran-binding protein 21
|
| Swissprots |
Q9NT89 Q9HAV4 Q9BZV5 Q9ULC9 Q96G48 Q5JTE6 Q96HN3 Q9BWM6 Q9H9M4 Q9NW39
|
| Accessions |
EAX04206 EAX04207 Q9HAV4 AB033117 BAA86605 AF271159 AAG53603 AF298880 AAG17907 AK001195 BAA91547 AK022718 BAB14200 AK023431 BAB14572 AK024301 BAG51288 AK025864 AK056619 BAG51767 AK127513 AK291452 BAF84141 AL137467 CAB70753 AL834207 BC000129 AAH00129 BC008347 AAH08347 BC009969 AAH09969 BC062635 AAH62635 BF108994 DB068849 NM_020750 NP_065801
|
| Function |
Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-media
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11777942}. Cytoplasm {ECO:0000269|PubMed:11777942}. Note=Shuttles between the nucleus and the cytoplasm.
|
| Tissue Specificity |
Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:11777942}.
|
| Top Pathways |
RNA transport
|
