XPO5

Gene Symbol	XPO5
Entrez Gene	57510
Alt Symbol	exp5
Species	Human
Gene Type	protein-coding
Description	exportin 5
Other Description	exportin-5|ran-binding protein 21
Swissprots	Q9NT89 Q9HAV4 Q9BZV5 Q9ULC9 Q96G48 Q5JTE6 Q96HN3 Q9BWM6 Q9H9M4 Q9NW39
Accessions	EAX04206 EAX04207 Q9HAV4 AB033117 BAA86605 AF271159 AAG53603 AF298880 AAG17907 AK001195 BAA91547 AK022718 BAB14200 AK023431 BAB14572 AK024301 BAG51288 AK025864 AK056619 BAG51767 AK127513 AK291452 BAF84141 AL137467 CAB70753 AL834207 BC000129 AAH00129 BC008347 AAH08347 BC009969 AAH09969 BC062635 AAH62635 BF108994 DB068849 NM_020750 NP_065801
Function	Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-media
Subcellular Location	Nucleus {ECO:0000269|PubMed:11777942}. Cytoplasm {ECO:0000269|PubMed:11777942}. Note=Shuttles between the nucleus and the cytoplasm.
Tissue Specificity	Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:11777942}.
Top Pathways	RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Exportin-5 protein fragment - ab132103 from Abcam Category Protein Source Wheat germ Species Human

XPO5 / Exportin 5 Antibody Blocking Peptide - LS-E3867 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

XPO5 / Exportin 5 Antibody Blocking Peptide - LS-E17281 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

XPO5 / Exportin 5 Antibody Blocking Peptide - LS-E17282 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Exportin-5 Protein - H00057510-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

XPO5-Antibody-C-term-Blocking-Peptide - BP16050b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

XPO5 Blocking Peptide - 33R-10360 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

XPO5 Blocking Peptide - 33R-5948 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

XPO5 Blocking Peptide - 33R-5489 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

XPO5 / Exportin-5 - H00057510-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

XPO5 / Exportin-5 - H00057510-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

XPO5 fusion protein - ag1267 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

XPO5 fusion protein - Ag24217 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

XPO5 fusion protein - ag8281 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Exportin 5 (XPO5) - RPF160Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Exportin 5 (XPO5) - RPF160Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Exportin-5(XPO5) ,partial - CSB-YP864014HU CSB-EP864014HU CSB-BP864014HU CSB-MP864014HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

XPO5 / Exportin-5 - TP309420 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Exportin-5 Protein - NBP1-89608PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

Exportin-5 Protein - NBP1-89607PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

Exportin-5 Recombinant Protein Antigen - NBP1-89606PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Exportin-5 Recombinant Protein Antigen - NBP1-89605PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

XPO5 Peptide, Human - M34GP17588H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Exportin 5 (XPO5) - RPU51008 from Biomatik Category Protein Prices $187.00, $324.00, $495.00, $619.20 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

XPO5 Recombinant Protein (OPCD00490) - OPCD00490 from Aviva Systems Biology Category Protein Source E.coli Species Human

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