XPO5

Gene Symbol XPO5
Entrez Gene 57510
Alt Symbol exp5
Species Human
Gene Type protein-coding
Description exportin 5
Other Description exportin-5|ran-binding protein 21
Swissprots Q9NT89 Q9HAV4 Q9BZV5 Q9ULC9 Q96G48 Q5JTE6 Q96HN3 Q9BWM6 Q9H9M4 Q9NW39
Accessions EAX04206 EAX04207 Q9HAV4 AB033117 BAA86605 AF271159 AAG53603 AF298880 AAG17907 AK001195 BAA91547 AK022718 BAB14200 AK023431 BAB14572 AK024301 BAG51288 AK025864 AK056619 BAG51767 AK127513 AK291452 BAF84141 AL137467 CAB70753 AL834207 BC000129 AAH00129 BC008347 AAH08347 BC009969 AAH09969 BC062635 AAH62635 BF108994 DB068849 NM_020750 NP_065801
Function Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-media
Subcellular Location Nucleus {ECO:0000269|PubMed:11777942}. Cytoplasm {ECO:0000269|PubMed:11777942}. Note=Shuttles between the nucleus and the cytoplasm.
Tissue Specificity Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:11777942}.
Top Pathways RNA transport

Exportin 5 (D7W6W) Rabbit mAb - 12565 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7W6W
Western blot analysis of extracts from various cell lines using Exportin 5 (D7W6W) Rabbit mAb.

Exportin 5 Antibody - 12068 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

Exportin 5 (A-11) - sc-271036 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Exportin 5 (A-11): sc-271036. Immunofluorescence staining of formalin-fixed HepG2 cells showing nuclear localization.

Exportin 5 (A-4) - sc-166789 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Exportin 5 (A-4): sc-166789. Western blot analysis of Exportin 5 expression in non-transfected: sc-117752 (A) and mouse Exportin 5 transfected: sc-120145 (B) 293T whole cell lysates.

Exportin 5 (E-16) - sc-34619 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Exportin 5 (E-16): sc-34619. Western blot analysis of Exportin 5 expression in U251-MG (A) and Ramos (B) whole cell lysates.

Exportin 5 (H-300) - sc-66885 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Exportin 5 (H-300): sc-66885. Western blot analysis of Exportin 5 expression in non-transfected: sc-110760 (A) and human Exportin 5 transfected: sc-110668 (B) 293 whole cell lysates.

Exportin 5 (P-13) - sc-34621 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Exportin 5 (P-13): sc-34621. Western blot analysis of Exportin 5 expression in HeLa whole cell lysate.

Exportin 5 (N-14) - sc-34620 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Exportin-5 antibody - ab57491 from Abcam

Prices $388.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-Exportin-5 antibody - ab167183 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-Exportin-5 antibody (ab167183) at 1/500 dilution + C32 cell lysate at 50 µg

Anti-Exportin-5 antibody - ab123667 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Exportin-5 antibody (ab123667) at 1/100 dilution + Human placenta tissue lysates at 35 µg

Anti-Exportin-5 antibody [EPR8452] - ab129006 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8452
Overlay histogram showing HEK293 cells stained with ab129006 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab129006, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was DyLight® 488 goat anti-rabbit IgG (H+L) (ab96899) at 1/500 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HEK293 cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-Exportin-5 antibody [EPR8453] - ab131281 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8453
All lanes : Anti-Exportin-5 antibody [EPR8453] (ab131281) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : K562 cell lysateLane 3 : 293T cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-XPO5 / Exportin 5 Antibody (aa1122-1152, AP) - LS-C273723 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XPO5 / Exportin 5 Antibody (aa1122-1152, APC) - LS-C273724 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XPO5 / Exportin 5 Antibody (aa1122-1152, Biotin) - LS-C273725 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XPO5 / Exportin 5 Antibody (aa1122-1152, FITC) - LS-C273726 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XPO5 / Exportin 5 Antibody (aa1122-1152, Azide-free, HRP) - LS-C273727 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XPO5 / Exportin 5 Antibody (aa1122-1152, PE) - LS-C273728 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XPO5 / Exportin 5 Antibody (aa1122-1152) - LS-C330303 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XPO5 / Exportin 5 Antibody (aa190-239) - LS-C145602 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
XPO5 / Exportin-5 antibody LS-C145602 Western blot of Rat Liver lysate. Antibody concentration 1 ug/ml.

Anti-XPO5 / Exportin 5 Antibody (aa182-231) - LS-C81104 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 6-18%.

Anti-XPO5 / Exportin 5 Antibody (aa1115-1164) - LS-C111151 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
XPO5 / Exportin-5 antibody LS-C111151 Western blot of Fetal Small Intestine lysate.

Anti-XPO5 / Exportin 5 Antibody - LS-C334948 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using XPO5 antibody.

Anti-XPO5 / Exportin 5 Antibody (aa1123-1152) - LS-C160667 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
XPO5 Antibody western blot of human placenta tissue lysates (35 ug/lane). The XPO5 antibody detected the XPO5 protein (arrow).
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