XPO5

Gene Symbol XPO5
Entrez Gene 57510
Alt Symbol exp5
Species Human
Gene Type protein-coding
Description exportin 5
Other Description exportin-5|ran-binding protein 21
Swissprots Q9NT89 Q9HAV4 Q9BZV5 Q9ULC9 Q96G48 Q5JTE6 Q96HN3 Q9BWM6 Q9H9M4 Q9NW39
Accessions EAX04206 EAX04207 Q9HAV4 AB033117 BAA86605 AF271159 AAG53603 AF298880 AAG17907 AK001195 BAA91547 AK022718 BAB14200 AK023431 BAB14572 AK024301 BAG51288 AK025864 AK056619 BAG51767 AK127513 AK291452 BAF84141 AL137467 CAB70753 AL834207 BC000129 AAH00129 BC008347 AAH08347 BC009969 AAH09969 BC062635 AAH62635 BF108994 DB068849 NM_020750 NP_065801
Function Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-media
Subcellular Location Nucleus {ECO:0000269|PubMed:11777942}. Cytoplasm {ECO:0000269|PubMed:11777942}. Note=Shuttles between the nucleus and the cytoplasm.
Tissue Specificity Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:11777942}.
Top Pathways RNA transport

Human-XPO5-cDNA-Clone - DC00060 from Abgent, a WuXi AppTec company

Prices $378.00
Sizes 10 µg
Species Human
Accession BC000129

XPO5 - MBS1277734 from MyBioSource

Species Human
Accession BC009969

XPO5 - MBS1267765 from MyBioSource

Species Human
Accession BC000129

Human XPO5 ORF Clone(NM_020750.2) - CDCR305811 from Creative Biomart

Species Human
Accession NM_020750.2

Human XPO5 ORF Clone(NM_020750.2) - CDCR305812 from Creative Biomart

Species Human
Accession NM_020750.2

Human XPO5 ORF Clone(NM_020750.2) - CDCL181431 from Creative Biomart

Species Human
Accession NM_020750.2

human XPO5 ORF clone - CDCH101824 from Creative Biomart

Species Human
Accession NM_020750

human XPO5 ORF clone - CDCH101825 from Creative Biomart

Species Human
Accession NM_020750

human XPO5 ORF clone - CDCH101826 from Creative Biomart

Species Human
Accession NM_020750

human XPO5 ORF clone - CDCH101827 from Creative Biomart

Species Human
Accession NM_020750

human XPO5 ORF clone - CDCH101828 from Creative Biomart

Species Human
Accession NM_020750

human XPO5 ORF clone - CDCH101829 from Creative Biomart

Species Human
Accession NM_020750

human XPO5 ORF clone - CDCH101830 from Creative Biomart

Species Human
Accession NM_020750

human XPO5 ORF clone - CDCH101831 from Creative Biomart

Species Human
Accession NM_020750

Human XPO5 ORF Clone(NM_020750.2) - CDCR305811 from Creative biogene

Species Human

Human XPO5 ORF Clone (BC000129) - CDCS415161 from Creative biogene

Species Human
Accession Q9HAV4

Human XPO5 ORF Clone (BC009969) - CDCS415162 from Creative biogene

Species Human
Accession Q9HAV4
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