| Gene Symbol | HCAR2 |
|---|---|
| Entrez Gene | 338442 |
| Alt Symbol | GPR109A, HCA2, HM74a, HM74b, NIACR1, PUMAG, Puma-g |
| Species | Human |
| Gene Type | protein-coding |
| Description | hydroxycarboxylic acid receptor 2 |
| Other Description | G protein-coupled receptor 109A|G protein-coupled receptor HM74a|G-protein coupled receptor 109A|G-protein coupled receptor HM74A|hydroxy-carboxylic acid receptor 2|niacin receptor 1|nicotinic acid receptor |
| Swissprots | Q8TDS4 A0PJL5 A7LGG3 |
| Accessions | ABS29270 BAB89345 BAC05891 BAC06094 CAD69365 Q8TDS4 AK290915 BAF83604 AL572062 AL698846 AY148884 AAN71621 BC027965 AAH27965 BC056419 AAH56419 BC063461 CD364466 NM_177551 NP_808219 |
| Function | Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5- methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. {ECO:0000269|PubMed:17932499}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:17932499}; Multi-pass membrane protein {ECO:0000269|PubMed:17932499}. |
| Tissue Specificity | Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils. {ECO:0000269|PubMed:12522134, ECO:0000269|PubMed:17932499}. |
| Top Pathways | cAMP signaling pathway |
G protein-coupled receptor 109A (GPR109A), ELISA Kit - MBS9315520 from MyBioSource
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G protein-coupled receptor 109A (GPR109A), ELISA Kit - MBS9313225 from MyBioSource
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G protein-coupled receptor 109A, GPR109A, ELISA Kit - MBS9300072 from MyBioSource
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G protein-coupled receptor 109A, GPR109A, ELISA Kit - MBS9300657 from MyBioSource
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Niacin Receptor 1 (NIACR1), ELISA Kit - MBS9312950 from MyBioSource
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Human GPR109A ELISA Kit - E015802 from Biobool
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Human NIACR1 ELISA Kit - E026504 from Biobool
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Human HCAR2 ELISA Kit - E085333 from Biobool
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Human G protein-coupled receptor 109A (GPR109A) ELISA Kit - AE62970HU from ARP American Research Products
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G Protein-Coupled Receptor 109A (GPR109A), ELISA Kit - MBS9397362 from MyBioSource
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G Protein-Coupled Receptor 109A (GPR109A), ELISA Kit - MBS9397370 from MyBioSource
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Niacin Receptor 1 (NIACR1), ELISA Kit - MBS9398221 from MyBioSource
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Niacin Receptor 1 (NIACR1), ELISA Kit - MBS9398229 from MyBioSource
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G Protein-Coupled Receptor 109A (GPR109A), ELISA Kit - MBS9397355 from MyBioSource
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