| Gene Symbol |
HCAR2
|
| Entrez Gene |
338442
|
| Alt Symbol |
GPR109A, HCA2, HM74a, HM74b, NIACR1, PUMAG, Puma-g
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hydroxycarboxylic acid receptor 2
|
| Other Description |
G protein-coupled receptor 109A|G protein-coupled receptor HM74a|G-protein coupled receptor 109A|G-protein coupled receptor HM74A|hydroxy-carboxylic acid receptor 2|niacin receptor 1|nicotinic acid receptor
|
| Swissprots |
Q8TDS4 A0PJL5 A7LGG3
|
| Accessions |
ABS29270 BAB89345 BAC05891 BAC06094 CAD69365 Q8TDS4 AK290915 BAF83604 AL572062 AL698846 AY148884 AAN71621 BC027965 AAH27965 BC056419 AAH56419 BC063461 CD364466 NM_177551 NP_808219
|
| Function |
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5- methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. {ECO:0000269|PubMed:17932499}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:17932499}; Multi-pass membrane protein {ECO:0000269|PubMed:17932499}.
|
| Tissue Specificity |
Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils. {ECO:0000269|PubMed:12522134, ECO:0000269|PubMed:17932499}.
|
| Top Pathways |
cAMP signaling pathway
|