HCAR2

Gene Symbol HCAR2
Entrez Gene 338442
Alt Symbol GPR109A, HCA2, HM74a, HM74b, NIACR1, PUMAG, Puma-g
Species Human
Gene Type protein-coding
Description hydroxycarboxylic acid receptor 2
Other Description G protein-coupled receptor 109A|G protein-coupled receptor HM74a|G-protein coupled receptor 109A|G-protein coupled receptor HM74A|hydroxy-carboxylic acid receptor 2|niacin receptor 1|nicotinic acid receptor
Swissprots Q8TDS4 A0PJL5 A7LGG3
Accessions ABS29270 BAB89345 BAC05891 BAC06094 CAD69365 Q8TDS4 AK290915 BAF83604 AL572062 AL698846 AY148884 AAN71621 BC027965 AAH27965 BC056419 AAH56419 BC063461 CD364466 NM_177551 NP_808219
Function Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5- methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. {ECO:0000269|PubMed:17932499}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:17932499}; Multi-pass membrane protein {ECO:0000269|PubMed:17932499}.
Tissue Specificity Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils. {ECO:0000269|PubMed:12522134, ECO:0000269|PubMed:17932499}.
Top Pathways cAMP signaling pathway

Human Puma gamma peptide - ab101077 from Abcam

Category Peptide

HCAR2 / NIACR1 Antibody Blocking Peptide - LS-E1854 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

HCAR2 / NIACR1 Blocking Peptide - LS-E23296 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

NIACR1-Antibody-Center-Blocking-peptide - BP12667c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

NIACR1 fusion protein - ag12438 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

NIACR1 fusion protein - ag12425 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

GPR109A - TP306527 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
GPR109A

HM74A/PUMA-G/GPR109A/NIACR1 Protein - NBP1-92180PEP from Novus Biologicals

Category Protein
Prices $209.00
Sizes 100 µl
Species Human

ChemiSCREEN™ Membrane Preparation Recombinant Human GPR109A Receptor - HTS201M from EMD Millipore

Prices $596.00
Sizes 200 units
Species Human

HCAR2 Peptide, Human - M34GP06868H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Hydroxycarboxylic acid receptor 2 (HCAR2), Recombinant Protein - MBS7016521 from MyBioSource

Category Protein
Prices $995.00, $1,500.00, $2,425.00
Sizes 10 µg, 50 µg, 100 µg
Source Cell Free Expression
Species Human

Recombinant Human HCAR2 Protein, MYC/DDK-tagged - HCAR2-1064H from Creative Biomart

Category Protein
Source HEK293
Species Human
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