PRKCB

Gene Symbol	PRKCB
Entrez Gene	5579
Alt Symbol	PKC-beta, PKCB, PRKCB1, PRKCB2
Species	Human
Gene Type	protein-coding
Description	protein kinase C, beta
Other Description	PKC-B|protein kinase C beta type|protein kinase C, beta 1 polypeptide
Swissprots	Q9UE50 D3DWF5 Q15138 C5IFJ8 O43744 Q9UEH8 P05127 Q9UE49 Q93060 Q9UJ33 Q9UJ30 P05771
Accessions	AAA60096 AAA60097 AAB97933 AAB97934 AAD13852 ACS14045 BAA00912 CAA05725 CAA29395 CAA29396 CAA44393 CAZ00742 EAW55796 EAW55797 EAW55798 EAW55799 P05771 AA613106 AI423262 AJ002788 AK057555 AK123381 AL833252 BC036472 AAH36472 BC045175 BI549165 DB456157 EU832791 ACE87802 GQ129253 ACT64387 M13975 AAA60095 X06318 CAA29634 X07109 CAA30130 NM_002738 NP_002729 NM_212535 NP_997700
Function	Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:20228790}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Top Pathways	Wnt signaling pathway, Tight junction, VEGF signaling pathway, Focal adhesion, Gap junction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HTScan® PKCβ I Kinase Assay Kit - 7582 from Cell Signaling Technology Category Assay Kit

HTScan® PKCβ II Kinase Assay Kit - 7585 from Cell Signaling Technology Category Assay Kit

Rat PRKCB / PKC-Beta ELISA Kit (Sandwich ELISA) - LS-F6363 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.057 ng/ml Range 0.156-10 ng/ml

Mouse/Human/Rat Phospho-PRKCB / PKC-Beta (Ser661) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1696 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human/Rat PRKCB / PKC-Beta ELISA Kit (Cell-Based ELISA) - LS-F2253 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Protein Kinase C beta II (PKC-bII), Human, ELISA Kit - CSB-E15925h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

PKCB Colorimetric Cell-Based ELISA Kit - CB5567 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

PKCB (Phospho-Ser661) Colorimetric Cell-Based ELISA Kit - CBP1766 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

protein kinase C, beta, ELISA Kit - MBS705739 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 7.8 pg/ml Range 31.25 pg/ml-2000 pg/ml

ELISA Kit for Protein Kinase C Beta 1 (PKCb1) - SEB045Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.065ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Protein Kinase C Beta 1 (PKCb1) - SEB045Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.057ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Protein Kinase C Beta Immunofluorescent Assay Kit - DIFT034 from Creative Diagnostics Category Immunofluorescence Kit

Human Protein Kinase C Beta Immunofluorescent Assay Kit - DIFT035 from Creative Diagnostics Category Immunofluorescence Kit

Human Protein Kinase C beta II(PKC-bII)ELISA Kit - CSB-E15925h from Cusabio Category ELISA Kit Sensitivity 7.8 pg/ml Range 31.25 pg/ml-2000 pg/ml

ELISA Kit for Protein Kinase C Beta 1 (PKCb1) - SEB045Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.065ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human PRKCB / PKC-Beta ELISA Kit (Sandwich ELISA) - LS-F21057 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 0.094 ng/ml Range 0.156-10 ng/ml

Rat PRKCB / PKC-Beta ELISA Kit (Sandwich ELISA) - LS-F21595 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 0.094 ng/ml Range 0.156-10 ng/ml

Human PRKCB / PKC-Beta ELISA Kit (Sandwich ELISA) - LS-F25256 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.065 ng/ml Range 0.156-10 ng/ml

PKCB ELISA Kit - DEIA-XYA1466 from Creative Diagnostics Category ELISA Kit

PKCB (Phospho-Ser661) ELISA Kit - DEIA-XYA1467 from Creative Diagnostics Category ELISA Kit

Human PRKCB / PKC-Beta ELISA Kit (Competitive EIA) - LS-F27775 from LifeSpan Bioscience Category ELISA Kit Prices $870.00 Sizes 1 plate Sensitivity 0.1 ng/ml Range 0.156-10 ng/ml

Rat PRKCB / PKC-Beta ELISA Kit (Competitive EIA) - LS-F28046 from LifeSpan Bioscience Category ELISA Kit Prices $870.00 Sizes 1 plate Sensitivity 0.5 Range 0.156-10 ng/ml

Human PRKCB ELISA Kit - E031617 from Biobool Category ELISA Kit Sensitivity 7.8 pg/ml

PRKCB ELISA Kit (Human) (OKCA01459) - OKCA01459 from Aviva Systems Biology Category ELISA Kit Prices $600.00 Sizes 96 wells Sensitivity 7.8 pg/mL Range 31.25 - 2,000 pg/mL

Human Protein Kinase C beta II (PKC-bII) ELISA Kit - AE25976HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 7.8 pg/mL Range 31.25-2000 pg/mL

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