PRKCB

Gene Symbol	PRKCB
Entrez Gene	5579
Alt Symbol	PKC-beta, PKCB, PRKCB1, PRKCB2
Species	Human
Gene Type	protein-coding
Description	protein kinase C, beta
Other Description	PKC-B|protein kinase C beta type|protein kinase C, beta 1 polypeptide
Swissprots	Q9UE50 D3DWF5 Q15138 C5IFJ8 O43744 Q9UEH8 P05127 Q9UE49 Q93060 Q9UJ33 Q9UJ30 P05771
Accessions	AAA60096 AAA60097 AAB97933 AAB97934 AAD13852 ACS14045 BAA00912 CAA05725 CAA29395 CAA29396 CAA44393 CAZ00742 EAW55796 EAW55797 EAW55798 EAW55799 P05771 AA613106 AI423262 AJ002788 AK057555 AK123381 AL833252 BC036472 AAH36472 BC045175 BI549165 DB456157 EU832791 ACE87802 GQ129253 ACT64387 M13975 AAA60095 X06318 CAA29634 X07109 CAA30130 NM_002738 NP_002729 NM_212535 NP_997700
Function	Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:20228790}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Top Pathways	Wnt signaling pathway, Tight junction, VEGF signaling pathway, Focal adhesion, Gap junction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PRKCB-Over-expression-Lysate - LY14290a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

PRKCB overexpression lysate - LY403957 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

PRKCB overexpression lysate - LY431009 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

PRKCB 293 Cell Lysate - 408953 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

PKC beta Overexpression Lysate (Native) - NBL1-14770 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

PKC β (h2): 293T Lysate - sc-177741 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

PRKCB Over-expression Lysate Product - GWB-1C0B65 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

PKC beta Overexpression Lysate (Native) - NBP2-04488 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

PKC beta Overexpression Lysate (Denatured) - H00005579-T02 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human PRKCB Knockdown Stable Cell Line - CSC-DC012398 from Creative biogene Category Cell Line Species Human

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