PRKCB
| Gene Symbol | PRKCB |
|---|---|
| Entrez Gene | 5579 |
| Alt Symbol | PKC-beta, PKCB, PRKCB1, PRKCB2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein kinase C, beta |
| Other Description | PKC-B|protein kinase C beta type|protein kinase C, beta 1 polypeptide |
| Swissprots | Q9UE50 D3DWF5 Q15138 C5IFJ8 O43744 Q9UEH8 P05127 Q9UE49 Q93060 Q9UJ33 Q9UJ30 P05771 |
| Accessions | AAA60096 AAA60097 AAB97933 AAB97934 AAD13852 ACS14045 BAA00912 CAA05725 CAA29395 CAA29396 CAA44393 CAZ00742 EAW55796 EAW55797 EAW55798 EAW55799 P05771 AA613106 AI423262 AJ002788 AK057555 AK123381 AL833252 BC036472 AAH36472 BC045175 BI549165 DB456157 EU832791 ACE87802 GQ129253 ACT64387 M13975 AAA60095 X06318 CAA29634 X07109 CAA30130 NM_002738 NP_002729 NM_212535 NP_997700 |
| Function | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:20228790}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
| Top Pathways | Wnt signaling pathway, Tight junction, VEGF signaling pathway, Focal adhesion, Gap junction |
Active human PKC beta 1 full length protein - ab60840 from Abcam
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Active human PKC beta 2 full length protein - ab60841 from Abcam
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Human PKC beta 1 full length protein - ab159198 from Abcam
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Human PKC beta 2 peptide - ab41780 from Abcam
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PRKCB / PKC-Beta Antibody Blocking Peptide - LS-E3508 from LifeSpan Bioscience
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PRKCB / PKC-Beta Antibody Blocking Peptide - LS-E20480 from LifeSpan Bioscience
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PRKCB / PKC-Beta Antibody Blocking Peptide - LS-E20479 from LifeSpan Bioscience
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PRKCB / PKC-Beta Antibody Blocking Peptide - LS-E8606 from LifeSpan Bioscience
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PRKCB / PKC-Beta Antibody Blocking Peptide - LS-E8607 from LifeSpan Bioscience
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PRKCB / PKC-Beta Antibody Blocking Peptide - LS-E27921 from LifeSpan Bioscience
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Recombinant Human PKC beta Protein - H00005579-P01 from Novus Biologicals
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PKC beta Recombinant Protein - P4188 from Novus Biologicals
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PKC beta Recombinant Protein - P3898 from Novus Biologicals
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PKC beta Recombinant Protein - P4755 from Novus Biologicals
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PKC beta Recombinant Protein - P4754 from Novus Biologicals
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PKC beta Recombinant Protein - P5030 from Novus Biologicals
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Recombinant PKC beta Protein - NBP1-99466 from Novus Biologicals
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PKC beta Peptide - P2102 from Novus Biologicals
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PKC beta Peptide - P2101 from Novus Biologicals
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PKC-beta2-Antibody-C-term-Blocking-Peptide - BP7016b from Abgent, a WuXi AppTec company
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PKC-beta12-Antibody-Center-Blocking-peptide - BP7016a from Abgent, a WuXi AppTec company
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Protein-Kinase-C-661-671 - SP3175b from Abgent, a WuXi AppTec company
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PKC beta 2 (Active) recombinant protein - GTX65210 from GeneTex
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PKC-b I Protein (OPPA01176) - OPPA01176 from Aviva Systems Biology
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PRKCB1 Blocking Peptide - 33R-5625 from Fitzgerald
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