PRKCB
| Gene Symbol | PRKCB |
|---|---|
| Entrez Gene | 5579 |
| Alt Symbol | PKC-beta, PKCB, PRKCB1, PRKCB2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein kinase C, beta |
| Other Description | PKC-B|protein kinase C beta type|protein kinase C, beta 1 polypeptide |
| Swissprots | Q9UE50 D3DWF5 Q15138 C5IFJ8 O43744 Q9UEH8 P05127 Q9UE49 Q93060 Q9UJ33 Q9UJ30 P05771 |
| Accessions | AAA60096 AAA60097 AAB97933 AAB97934 AAD13852 ACS14045 BAA00912 CAA05725 CAA29395 CAA29396 CAA44393 CAZ00742 EAW55796 EAW55797 EAW55798 EAW55799 P05771 AA613106 AI423262 AJ002788 AK057555 AK123381 AL833252 BC036472 AAH36472 BC045175 BI549165 DB456157 EU832791 ACE87802 GQ129253 ACT64387 M13975 AAA60095 X06318 CAA29634 X07109 CAA30130 NM_002738 NP_002729 NM_212535 NP_997700 |
| Function | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:20228790}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
| Top Pathways | Wnt signaling pathway, Tight junction, VEGF signaling pathway, Focal adhesion, Gap junction |
PKC β siRNA (h) - sc-29450 from Santa Cruz Biotechnology
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PKC β shRNA Plasmid (h) - sc-29450-SH from Santa Cruz Biotechnology
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PKC β shRNA (h) Lentiviral Particles - sc-29450-V from Santa Cruz Biotechnology
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PKC βII siRNA (h) - sc-39170 from Santa Cruz Biotechnology
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PKC βII shRNA Plasmid (h) - sc-39170-SH from Santa Cruz Biotechnology
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PKC βII shRNA (h) Lentiviral Particles - sc-39170-V from Santa Cruz Biotechnology
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PKC beta RNAi - H00005579-R08 from Novus Biologicals
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PKC beta RNAi - H00005579-R07 from Novus Biologicals
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MISSION® esiRNA - EHU069171 from Sigma-Aldrich
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MISSION® siRNA - SIHK1822 from Sigma-Aldrich
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MISSION® siRNA - SIHK1823 from Sigma-Aldrich
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MISSION® siRNA - SIHK1821 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1569 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1569 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08527 from Sigma-Aldrich
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PRKCB siRNA (Human) - CRH3749 from Cohesion Biosciences
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shRNA set against Human PRKCB (NM_002738.6) - SHH382792 from Creative biogene
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Human PRKCB siRNA - orb264251 from Biorbyt
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PRKCB shRNA Plasmid (Human) - CHH3749 from Cohesion Biosciences
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PRKCB miRNA 3'UTR clone - MiUTR1H-08271 from Creative biogene
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PRKCB miRNA 3'UTR clone - MiUTR1H-08272 from Creative biogene
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