PRKCB

Gene Symbol	PRKCB
Entrez Gene	5579
Alt Symbol	PKC-beta, PKCB, PRKCB1, PRKCB2
Species	Human
Gene Type	protein-coding
Description	protein kinase C, beta
Other Description	PKC-B|protein kinase C beta type|protein kinase C, beta 1 polypeptide
Swissprots	Q9UE50 D3DWF5 Q15138 C5IFJ8 O43744 Q9UEH8 P05127 Q9UE49 Q93060 Q9UJ33 Q9UJ30 P05771
Accessions	AAA60096 AAA60097 AAB97933 AAB97934 AAD13852 ACS14045 BAA00912 CAA05725 CAA29395 CAA29396 CAA44393 CAZ00742 EAW55796 EAW55797 EAW55798 EAW55799 P05771 AA613106 AI423262 AJ002788 AK057555 AK123381 AL833252 BC036472 AAH36472 BC045175 BI549165 DB456157 EU832791 ACE87802 GQ129253 ACT64387 M13975 AAA60095 X06318 CAA29634 X07109 CAA30130 NM_002738 NP_002729 NM_212535 NP_997700
Function	Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:20228790}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Top Pathways	Wnt signaling pathway, Tight junction, VEGF signaling pathway, Focal adhesion, Gap junction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PRKCB Gene cDNA Clone - orb144858 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human-PRKCB-cDNA-Clone - DC07049 from Abgent, a WuXi AppTec company Prices $908.55 Sizes 10 µg Species Human Accession BC036472

PRKCB - MBS1273959 from MyBioSource Species Human Accession BC036472

Human PRKCB ORF clone(NM_002738.6) - CDCL185823 from Creative Biomart Species Human Accession NM_002738.6

Human PRKCB Gene ORF cDNA clone in cloning vector - HG10750-U from Sino Biological Species Human

Human PRKCB Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10750-CF from Sino Biological Species Human

Human PRKCB Gene ORF cDNA clone expression plasmid, C-HA tag - HG10750-CY from Sino Biological Species Human

Human PRKCB Gene cDNA Clone (full-length ORF Clone) expression ready, untagged - HG10750-U-N from Sino Biological Species Human Accession NM_002738.6

Human PRKCB Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10750-CM from Sino Biological Species Human

Human PRKCB Gene ORF cDNA clone expression plasmid, N-HA tag - HG10750-NY from Sino Biological Species Human

Human PRKCB Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10750-U-F from Sino Biological Species Human

Human PRKCB Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10750-ANG from Sino Biological Species Human

Human PRKCB Gene ORF cDNA clone expression plasmid, C-His tag - HG10750-CH from Sino Biological Species Human

Human PRKCB Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10750-ACR from Sino Biological Species Human

Human PRKCB Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG10750-ANR from Sino Biological Species Human

Human PRKCB Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10750-ACG from Sino Biological Species Human

Human PRKCB Gene ORF cDNA clone expression plasmid - HG10750-UT from Sino Biological Species Human

Human PRKCB Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10750-NF from Sino Biological Species Human

Human PRKCB Gene ORF cDNA clone expression plasmid, N-His tag - HG10750-NH from Sino Biological Species Human

Human PRKCB Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10750-NM from Sino Biological Species Human

Human PRKCB ORF clone(NM_002738.6) - CDCL185823 from Creative biogene Species Human

human PRKCB ORF clone (NM_212535.2) - CDCH067818 from Creative biogene Species Human

Human PRKCB ORF Clone (BC036472) - CDCS410930 from Creative biogene Species Human Accession P05771

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