CYTH2

Gene Symbol	CYTH2
Entrez Gene	9266
Alt Symbol	ARNO, CTS18, CTS18.1, PSCD2, PSCD2L, SEC7L, Sec7p-L, Sec7p-like
Species	Human
Gene Type	protein-coding
Description	cytohesin 2
Other Description	ARF exchange factor|ARF nucleotide-binding site opener|CTC-273B12.8|PH, SEC7 and coiled-coil domain-containing protein 2|cytohesin-2|pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2)|pleckstrin homology, Sec7 and coiled/coil domains 2 (cytohesin-2)
Swissprots	A8K8P0 Q8IXY9 Q92958 Q99418
Accessions	EAW52349 EAW52350 EAW52351 Q99418 AB209573 BAD92810 AF318380 AAL55887 AK091443 AK292405 BAF85094 AK299590 BAG61522 BC004361 AAH04361 BC012771 BC035646 BC036615 BC038713 AAH38713 BC042153 BC047631 DC344850 DQ892565 ABM83491 DQ896856 ABM87855 HG510916 U59752 AAB17532 U70728 AAB09591 X99753 CAA68084 XM_006723472 XP_006723535 XM_006723473 XP_006723536 NM_004228 NP_004219 NM_017457 NP_059431
Function	Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane. {ECO:0000269|PubMed:17398095}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:17398095}; Peripheral membrane protein {ECO:0000269|PubMed:17398095}. Cytoplasm {ECO:0000269|PubMed:17398095}. Note=Both isoform 1 and isoform 2 are recruited to the cell membrane through their association with ARL4A, ARL4C and ARL4D. They require also interaction with phosphoinositides for targeting to the plasma membrane.
Tissue Specificity	Ubiquitous.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Cytohesin 2 full length protein - ab134606 from Abcam Category Protein Source E. coli Species Human

CYTH2 / Cytohesin 2 Antibody Blocking Peptide - LS-E1512 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CYTH2 / Cytohesin 2 Antibody Blocking Peptide - LS-E24940 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CYTH2 / Cytohesin 2 Antibody Blocking Peptide - LS-E26526 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Cytohesin 2 Partial Recombinant Protein - H00009266-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Cytohesin 2 Recombinant Protein - H00009266-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Cytohesin 2 Protein - NBP2-22983 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

PSCD2-Antibody-N-term-Blocking-peptide - BP12239a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Cytohesin 2 blocking peptide - GTX88930-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Human CYTH2 protein - orb168191 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

CYTH2 protein (His tag) - 80R-2504 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

Cytohesin 2 Peptide - AC21-1362-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Cytohesin 2 (1-399, His-tag) - AR50576PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

Cytohesin 2 (1-399, His-tag) - AR50576PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

Cytohesin 2 - H00009266-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Cytohesin 2 - H00009266-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Cytohesin 2 - H00009266-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Cytohesin 2 - H00009266-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CYTH2, 1-399aa, Human, His tag, E.coli - 01-P1752 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

ARNO Peptide - 45-288P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human, Rat

CYTH2 fusion protein - ag0559 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CYTH2 fusion protein - Ag0687 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

CYTH2 Human - PRPS-1255 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source E.coli. Species Human

CYTH2, 1-399aa, Recombinant Protein - GWB-P0286M from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human Cytohesin 2, His-tagged - CYTH2-7184H from Creative Biomart Category Protein Source E. coli Species Human

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