CYTH2

Gene Symbol CYTH2
Entrez Gene 9266
Alt Symbol ARNO, CTS18, CTS18.1, PSCD2, PSCD2L, SEC7L, Sec7p-L, Sec7p-like
Species Human
Gene Type protein-coding
Description cytohesin 2
Other Description ARF exchange factor|ARF nucleotide-binding site opener|CTC-273B12.8|PH, SEC7 and coiled-coil domain-containing protein 2|cytohesin-2|pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2)|pleckstrin homology, Sec7 and coiled/coil domains 2 (cytohesin-2)
Swissprots A8K8P0 Q8IXY9 Q92958 Q99418
Accessions EAW52349 EAW52350 EAW52351 Q99418 AB209573 BAD92810 AF318380 AAL55887 AK091443 AK292405 BAF85094 AK299590 BAG61522 BC004361 AAH04361 BC012771 BC035646 BC036615 BC038713 AAH38713 BC042153 BC047631 DC344850 DQ892565 ABM83491 DQ896856 ABM87855 HG510916 U59752 AAB17532 U70728 AAB09591 X99753 CAA68084 XM_006723472 XP_006723535 XM_006723473 XP_006723536 NM_004228 NP_004219 NM_017457 NP_059431
Function Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane. {ECO:0000269|PubMed:17398095}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:17398095}; Peripheral membrane protein {ECO:0000269|PubMed:17398095}. Cytoplasm {ECO:0000269|PubMed:17398095}. Note=Both isoform 1 and isoform 2 are recruited to the cell membrane through their association with ARL4A, ARL4C and ARL4D. They require also interaction with phosphoinositides for targeting to the plasma membrane.
Tissue Specificity Ubiquitous.
Top Pathways Endocytosis

cytohesin-1/2 (C-20) - sc-9729 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
cytohesin-1/2 (C-20): sc-9729. Western blot analysis of cytohesin-1 expression in non-transfected: sc-117752 (A) and human cytohesin-1 transfected: sc-116153 (B) 293T whole cell lysates.

cytohesin-1/2 (D-11) - sc-166542 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cytohesin-1/2 (D-11): sc-166542. Western blot analysis of cytohesin-1 expression in non-transfected: sc-117752 (A) and human cytohesin-1 transfected: sc-116153 (B) 293T whole cell lysates.

cytohesin-2 (H-37) - sc-292564 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
cytohesin-2 (H-37): sc-292564. Western blot analysis of cytohesin-2 expression in non-transfected: sc-117752 (A) and human cytohesin-2 transfected: sc-176453 (B) 293T whole cell lysates.

cytohesin-2 (H-7) - sc-374640 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cytohesin-2 (H-7): sc-374640. Western blot analysis of cytohesin-2 expression in non-transfected: sc-117752 (A) and human cytohesin-2 transfected: sc-176453 (B) 293T whole cell lysates.

cytohesin-2 (N-20) - sc-9727 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
cytohesin-2 (N-20): sc-9727. Immunoperoxidase staining of formalin fixed, paraffin-embedded human spleen tissue showing cytoplasmic staining of cells in white pulp and cells in red pulp.

cytohesin-2 (CYT2-21) - sc-59451 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
cytohesin-2 (CYT2-21): sc-59451. Western blot analysis of cytohesin-2 expression in non-transfected: sc-117752 (A) and human cytohesin-2 transfected: sc-176453 (B) 293T whole cell lysates.

Anti-Cytohesin 2 antibody - ab56510 from Abcam

Prices $401.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Cytohesin 2 antibody (ab56510) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human colon.

Anti-Cytohesin 2 antibody - ab151219 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Cytohesin 2 antibody [10A12] - ab2728 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 10A12
Immunocytochemistry/Immunofluorescence analysis of Cytohesin 2 in HeLa cells. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with ab2728 (1:100) overnight at 4°C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody. Cytohesin 2 staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Images were taken at 60X magnification.

Anti-Cytohesin 2 antibody [CYT2-21] - ab12421 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone CYT2-21

Anti-CYTH2 / Cytohesin 2 Antibody (aa35-64, AP) - LS-C216979 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYTH2 / Cytohesin 2 Antibody (aa35-64, APC) - LS-C216980 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYTH2 / Cytohesin 2 Antibody (aa35-64, Biotin) - LS-C216981 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYTH2 / Cytohesin 2 Antibody (aa35-64, FITC) - LS-C216982 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYTH2 / Cytohesin 2 Antibody (aa272-321) - LS-C186949 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of Human MDA-MB-435S. CYTH2 antibody dilution 1.0 ug/ml.

Anti-CYTH2 / Cytohesin 2 Antibody (aa35-64, Azide-free, HRP) - LS-C216983 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYTH2 / Cytohesin 2 Antibody (aa35-64, PE) - LS-C216984 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYTH2 / Cytohesin 2 Antibody (aa35-64) - LS-C162207 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
PSCD2 Antibody western blot of mouse kidney tissue lysates (35 ug/lane). The PSCD2 antibody detected the PSCD2 protein (arrow).

Anti-CYTH2 / Cytohesin 2 Antibody (aa35-64) - LS-C324344 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYTH2 / Cytohesin 2 Antibody (aa314-399, Azide-free) - LS-C327153 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CYTH2 / Cytohesin 2 Antibody (clone 6H5) - LS-C105077 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 6H5
Immunofluorescence of monoclonal antibody to PSCD2 on HeLa cell (antibody concentration 10 ug/ml).

Anti-CYTH2 / Cytohesin 2 Antibody - LS-C346195 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Immunofluorescence blot of U20S cell using CYTH2 antibody. Blue: DAPI for nuclear staining.

Anti-CYTH2 / Cytohesin 2 Antibody - LS-C64224 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CYTH2 / Cytohesin 2 Antibody (N-Terminus) - LS-C54538 from LifeSpan Bioscience

Host Goat
Clonality Polyclonal
Antibody (0.5 ug/ml) staining of Human Brain (Cerebellum) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Cytohesin 2 Antibody (6H5) - H00009266-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6H5
Western Blot: Cytohesin 2 Antibody (6H5) [H00009266-M02] - CYTH2 monoclonal antibody (M02), clone 6H5 Analysis of CYTH2 expression in PC-12.
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