TYRO3

Gene Symbol TYRO3
Entrez Gene 7301
Alt Symbol BYK, Dtk, Etk-2, RSE, Rek, Sky, Tif
Species Human
Gene Type protein-coding
Description TYRO3 protein tyrosine kinase
Other Description tyrosine-protein kinase DTK|tyrosine-protein kinase RSE|tyrosine-protein kinase SKY|tyrosine-protein kinase TIF|tyrosine-protein kinase byk|tyrosine-protein kinase receptor TYRO3
Swissprots Q86VR3 O14953 Q06418
Accessions BAA05134 EAW92506 EAW92507 EAW92508 Q06418 AB209431 BAD92668 AK022124 AK131389 AK295496 BAG58416 BC029925 AAH29925 BC034960 BC049368 AAH49368 BC051756 AAH51756 D17517 BAA04467 D50479 BAA21781 DB483422 U02566 AAA17407 U05682 AAA19236 X72886 CAA51396 XM_011521992 XP_011520294 XM_011521993 XP_011520295 NM_006293 NP_006284
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppre
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Abundant in the brain and lower levels in other tissues.

Tyro3 (D38C6) Rabbit mAb - 5585 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D38C6
Western blot analysis of extracts from COS-7 cells, and tissues from human and mouse brain using Tyro3 (D38C6) Rabbit mAb.

Tyro3 (C-20) - sc-1095 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Tyro3 (C-20): sc-1095. Western blot analysis of Tyro3 expression in Hep G2 whole cell lysate (A) and mouse brain extract (B).

Tyro3 (H-110) - sc-20742 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Tyro3 (H-110): sc-20742. Western blot analysis of Tyro3 expression in non-transfected: sc-117752 (A) and human Tyro3 transfected: sc-116151 (B) 293T whole cell lysates.

Tyro3 (1C11E8) - sc-81160 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Tyro3 (N-18) - sc-1094 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Tyro3 (N-18): sc-1094. Western blot analysis of Tyro3 expression in Hep G2 (A) and MCF7 (B) whole cell lysates.

Tyro3 (9A3F2) - sc-81161 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Tyro3 (A-7) - sc-166359 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Tyro3 (A-7): sc-166359. Western blot analysis of Tyro3 expression in non-transfected: sc-117752 (A) and human Tyro3 transfected: sc-116151 (B) 293T whole cell lysates.

Tyro3 (6D6F10) - sc-130073 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Tyro3 (B-4) - sc-166360 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Tyro3 (B-4): sc-166360. Western blot analysis of Tyro3 expression in non-transfected: sc-117752 (A) and human Tyro3 transfected: sc-116151 (B) 293T whole cell lysates.

Anti-TYRO3 antibody - ab79778 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TYRO3 antibody (ab79778) at 1 µg/mlLane 1 : Brain (Mouse) Tissue LysateLane 2 : Brain (Rat) Tissue Lysate Lane 3 : U-87 MG (Human glioblastoma astrocytoma) Whole Cell LysateLane 4 : SHSY-5Y (Human neuroblastoma cell line) Whole Cell LysateLane 5 : SK N BE (Human neuroblastoma) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-TYRO3 antibody - ab37839 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TYRO3 antibody (ab37839) + Mouse brain lysate.SecondaryHRP-anti-rabbitdeveloped using the ECL technique

Anti-TYRO3 antibody - ab37841 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TYRO3 antibody (ab37841) + mouse brain lysateSecondaryHRP-anti-rabbitdeveloped using the ECL technique

Anti-TYRO3 antibody - ab176026 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed, paraffin embedded Human brain tissue labeling TYRO3 with ab176026 at 1/10, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

Anti-TYRO3 antibody [1C11E8, 1C11B2, 9A3F2] - ab54222 from Abcam

Host Mouse
Clonality Monoclonal
Clone 1C11E8, 1C11B2, 9A3F2
Lane 1 : Molecular weight markersLane 2 : Anti-TYRO3 antibody [1C11E8, 1C11B2, 9A3F2] (ab54222) at 1/500 dilutionLane 1 : Molecular weight markersLane 2 : Truncated Tyro3 recombinant protein

Anti-TYRO3 antibody [5B7] - ab117877 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5B7
Immunofluorescent staining of COS7 cells transiently transfected with pCMV6-ENTRY TYRO3, labelled with ab117877 at 1/100 dilution.

Anti-TYRO3 antibody [6D6F10] - ab70397 from Abcam

Host Mouse
Clonality Monoclonal
Clone 6D6F10
ab70397 at 1/50 dilution staining TYRO3 in Methanol-fixed HeLa cells by Immunofluorsence

Anti-TYRO3 antibody [EPR4308] - ab109231 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4308
All lanes : Anti-TYRO3 antibody [EPR4308] (ab109231) at 1/1000 dilutionLane 1 : fetal brain lysatesLane 2 : fetal hippocampus lysatesLane 3 : MCF7 cell lysatesLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-TYRO3 Antibody - LS-C41434 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-TYRO3 Antibody - LS-C76640 from LifeSpan Bioscience

Prices $325.00
Sizes 40 µg
Host Mouse
Clonality Monoclonal

Anti-TYRO3 Antibody (clone 10E11) - LS-C109082 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 10E11
Western blot using TYRO3 mouse monoclonal antibody against extracellular domain of human TYRO3 (aa41-429).

Anti-TYRO3 Antibody (clone 6D6F10) - LS-C109116 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6D6F10
Immunofluorescence of HeLa (Left) and MCF-7 (Right) cells using Tyro3 mouse monoclonal antibody (green).

Anti-TYRO3 Antibody (clone 64CT15.6.2.3.1) - LS-C96489 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Mouse
Clonality Monoclonal
Clone 64CT15.6.2.3.1
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with TYRO3 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-TYRO3 Antibody (clone 1C10E8, 9A3F2) - LS-C47224 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-TYRO3 Antibody - LS-C124746 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-TYRO3 Antibody (C-Terminus) - LS-C99134 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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