TYRO3

Gene Symbol	TYRO3
Entrez Gene	7301
Alt Symbol	BYK, Dtk, Etk-2, RSE, Rek, Sky, Tif
Species	Human
Gene Type	protein-coding
Description	TYRO3 protein tyrosine kinase
Other Description	tyrosine-protein kinase DTK|tyrosine-protein kinase RSE|tyrosine-protein kinase SKY|tyrosine-protein kinase TIF|tyrosine-protein kinase byk|tyrosine-protein kinase receptor TYRO3
Swissprots	Q86VR3 O14953 Q06418
Accessions	BAA05134 EAW92506 EAW92507 EAW92508 Q06418 AB209431 BAD92668 AK022124 AK131389 AK295496 BAG58416 BC029925 AAH29925 BC034960 BC049368 AAH49368 BC051756 AAH51756 D17517 BAA04467 D50479 BAA21781 DB483422 U02566 AAA17407 U05682 AAA19236 X72886 CAA51396 XM_011521992 XP_011520294 XM_011521993 XP_011520295 NM_006293 NP_006284
Function	Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppre
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Abundant in the brain and lower levels in other tissues.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Phosphotyrosine TYRO3 / Tyrosine-protein Kinase Receptor TYRO3 ELISA Kit - RAB0940 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Human TYRO3 / Tyrosine-protein Kinase Receptor TYRO3 ELISA Kit - RAB0650 from Sigma-Aldrich Category ELISA Kit Prices $633.00 Sizes 1 kt

Mouse TYRO3 ELISA Kit (Sandwich ELISA) - LS-F379 from LifeSpan Bioscience Category ELISA Kit Prices $670.00, $1,190.00, $2,570.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 0.41 ng/ml Range 0.41-40 ng/ml

Human TYRO3 ELISA Kit (Custom ELISA) - LS-F342 from LifeSpan Bioscience Category ELISA Kit Prices $670.00, $1,190.00, $2,570.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity To be determined Range 0.41-40 ng/ml

Human Dtk DuoSet ELISA - DY859 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 62.50 - 4,000 pg/mL

Human Total Dtk DuoSet IC ELISA, 2 Plate - DYC5600-2 from R&D Systems Category ELISA Kit Prices $329.00 Sizes 1 kit (for 2 Plates) Range 125.00 - 8,000 pg/mL

Mouse Dtk DuoSet ELISA - DY759 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 125.00 - 8,000 pg/mL

Tyrosine-protein kinase receptor TYRO3 (TYRO3), Human, ELISA Kit - CSB-EL025396HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Tyrosine-protein kinase receptor TYRO3 (TYRO3), Human, ELISA Kit - E01T0746 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Human DTK ELISA - ELH-DTK from RayBiotech Category ELISA Kit Prices $390.00, $702.00, $1,561.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 40 pg/ml Range 40 pg/ml - 10,000 pg/ml

Thrombus Precursor Protein, ELISA Kit - MBS031488 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Thrombus Precursor Protein, ELISA Kit - MBS024839 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Thrombus Precursor Protein, ELISA Kit - MBS065294 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Thrombus Precursor Protein, ELISA Kit - MBS026911 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Thrombus Precursor Protein, ELISA Kit - MBS007714 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Thrombus Precursor Protein, ELISA Kit - MBS041251 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Thrombus Precursor Protein, ELISA Kit - MBS043853 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Thrombus Precursor Protein, ELISA Kit - MBS023136 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Thrombus Precursor Protein, ELISA Kit - MBS045923 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Thrombus Precursor Protein, ELISA Kit - MBS083045 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Thrombus Precursor Protein, ELISA Kit - MBS040313 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Thrombus Precursor Protein, ELISA Kit - MBS042925 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Thrombus Precursor Protein, ELISA Kit - MBS105903 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Thrombus Precursor Protein, ELISA Kit - MBS039612 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Thrombus Precursor Protein, ELISA Kit - MBS057277 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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